Associating Sonic Temporal Structures with Actions

将声音时间结构与动作相关联

• 批准号: 7120478
• 负责人: Bradley W. Vines
• 金额: $ 0.84万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2007-01-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120478
• 关键词: aphasia; association learning; auditory stimulus; behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; clinical research; communication disorder diagnosis; frontal lobe /cortex; functional ability; functional magnetic resonance imaging; human subject; neural plasticity; postdoctoral investigator; psychological tests; psychomotor function; sound perception; stroke; transcranial magnetic stimulation

DESCRIPTION (provided by applicant): The proposed research investigates areas of the brain that adapt in order to associate actions with temporal sound patterns. The development of action-sound associations is essential for behaviorally relevant sound mappings, including production and perception of speech and music. Neural plasticity will be compared across groups with and without lesions (both real and rTMS induced "virtual" lesions) to left ventral prefrontal cortex (PFCv) to examine short and long-term plasticity in brain regions associated with language recovery from Broca's aphasia. Three proposed experiments, using complimentary research techniques - fMRI and rTMS, test hypotheses concerning a learned somatotopic mapping in premotor cortex for processing meaningful temporal structures, and the effect of re-mapping action to non-verbal sound on clinical language recovery. Neuroimaging measurements will be collected from participants as they discriminate between sequences of sine tones before and after training new associations between hand movements and the sound patterns. Findings will be relevant to the development of recovery methods for victims of stroke and to fundamental issues in brain adaptation for sensory-action pairings.

描述（由申请人提供）：拟议的研究调查了调整大脑的区域，以将动作与时间模式相关联。 动作相关联想的发展对于行为相关的声音映射至关重要，包括对语音和音乐的产生和感知。将在有或没有病变的组（实际和RTMS诱导的“虚拟”病变）到左侧腹侧前额叶皮层（PFCV）之间比较神经可塑性，以检查与Broca失语症的语言恢复相关的大脑区域的短期和长期可塑性。三个提出的实验，使用免费研究技术 - fMRI和RTMS，测试了关于在处理前皮层中学习的体育型映射的假设，用于处理有意义的时间结构，以及将行动重新映射到非言语声音对临床语言恢复的影响。神经影像学测量将从参与者中收集，因为他们在训练手动运动和声音模式之间训练新的关联之前和之后歧视正弦音调的序列。调查结果将与中风受害者的恢复方法的发展以及感官表演配对的大脑适应性问题有关。