Androgens and molecular mediators of motoneuron repair

雄激素和运动神经元修复的分子介质

• 批准号: 7112696
• 负责人: KEITH N FARGO
• 金额: $ 4.4万
• 依托单位: LOYOLA UNIVERSITY CHICAGO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-05-15 至 2009-05-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112696
• 关键词: androgens; injury; male; motor neurons; proteins; testosterone

DESCRIPTION (provided by applicant): Motoneuron injury and degeneration are important medical issues, with thousands of people diagnosed with spinal motoneuron diseases, spinal cord injuries, and peripheral nerve injuries every year. The long-term goals of this proposal are to contribute to our understanding of the motoneuron's cellular and molecular response to injury. Using a variety of molecular neuroscience techniques, I will study the relationship of steroid hormones to a novel protein (neuritin) thought to be involved in the ability of neurons to change their overall shape, and therefore their functional connectivity. Additionally, I will examine the relationship between steroid hormones and the immune system in promoting neuronal survival in the central nervous system following axonal injury. Techniques to be used include in situ hybridization, immunocytochemistry, electron microscopy, and the use of transgenic mice. This research could potentially lead to future treatment strategies for traumatic nerve injuries and neurodegenerative diseases.

描述（由申请人提供）：运动神经元损伤和变性是重要的医疗问题，每年有成千上万的人被诊断出患有脊柱运动神经元疾病，脊髓损伤和周围神经损伤。该提案的长期目标是为我们理解运动神经元的细胞和分子对损伤的反应做出贡献。使用多种分子神经科学技术，我将研究类固醇激素与一种被认为与神经元改变其整体形状以及其功能连接性的能力有关的新型蛋白质（神经素）的关系。此外，我将研究类固醇激素与免疫系统在轴突损伤后促进中枢神经系统中神经元存活方面的关系。要使用的技术包括原位杂交，免疫细胞化学，电子显微镜和转基因小鼠的使用。这项研究可能会导致创伤神经损伤和神经退行性疾病的未来治疗策略。