BIOMEDICAL NMR LABORATORY

生物医学核磁共振实验室

• 批准号: 7336026
• 负责人: PAUL P WANG
• 金额: $ 28.22万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2007-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7336026
• 关键词: BIOMEDICAL; NMR; LABORATORY

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this program year we, along with the Laboratory of Molecular Computations and Bioinformatics, pursued introduction of our combined capabilities to the wider university community through presenting seminars in the Departments of Chemistry and Biology. These two departments we anticipate to offer substantial opportunities for building future collaborations that engage RCMI staff and resources. We used these opportunities to discuss some of our current ongoing research activities, currently available resources, and emerging new resources and the types of experimental studies that they can support. We participated very actively in this year's International RCMI Symposium on Health Disparities, held in December 2004 at Baltimore, MD. We made five presentations on projects supported by the Core at this meeting. Overall, we have made ten abstracted presentations of work supported by the core this year. We have also added at least two new collaborative projects to our portfolio of activities. The installation of an extensive equipment upgrade for the 400 MHz spectrometer was begun in March of 2005, a major culminating objective of the funding of this core component of the program. This upgrade includes a two-channel transmitter/receiver configuration for double resonance experiments, a digital 28-shim magnet homogeneity system, a biological and materials microimaging accessory with high-powered field gradients, and several probes for detection of a wide range of biologically relevant nuclei. Completion of installation is anticipated to occur in April of 2005. Specialized training of facility staff in operation of the instrumentation will commence in the spring and summer of 2005 through course-vouchers provided by instrument vendor, Bruker Biospin. With Dr. Wang's leadership, we succeeded in being awarded a training grant in molecular imaging sciences from the US Army. US Army Medical Command (Wang) 07/01/2005-06/30/2009 A Partnership Training Program In Breast Cancer Research Using Molecular Imaging Techniques This is a training partnership program, with Dr. Bhujwalla at Johns Hopkins University, to train faculty at Howard University in molecular imaging principles and practices. This program has two components: a collaborative research component and a training component. The research component includes two projects using MRI and optical imaging techniques to study the functions of macrophage in tumor bearing animals. The training component includes organizing workshops, symposiums and lab internships for the trainees.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。在这个计划的年份中，我们与分子计算和生物信息学实验室一起通过在化学和生物学部门介绍研讨会来追求我们向更广泛的大学社区的合并能力。我们希望这两个部门为建立与RCMI员工和资源的未来合作提供大量机会。我们利用这些机会讨论了我们当前正在进行的研究活动，目前可用的资源以及新的资源以及他们可以支持的实验研究类型。 我们非常积极地参加了今年的国际RCMI健康差异研讨会，该研讨会于2004年12月在马里兰州巴尔的摩举行。我们在这次会议上对核心支持的项目进行了五次演讲。总体而言，我们已经做了十年核心支持的十个抽象作品。我们还为我们的活动组合添加了至少两个新的合作项目。 2005年3月开始为400 MHz光谱仪安装广泛的设备升级，这是该计划的核心组成部分资助的主要最终目标。该升级包括用于双谐振实验的两通道发射机/接收器配置，一种数字28-SHIM磁铁同质性系统，具有高功率现场梯度的生物学和材料微成像配件，以及用于检测广泛相关核的几种探针。预计安装的完成预计将于2005年4月进行。对仪器运营的设施人员的专业培训将于2005年春季和夏季通过仪器供应商Bruker Biospin提供的课程票房开始。 在Wang博士的领导下，我们成功地获得了美国陆军分子成像科学的培训补助金。 美国陆军医疗司令部（WANG）07/01/2005-06/30/2009使用分子成像技术进行乳腺癌研究的伙伴关系培训计划这是一项培训合作计划，与约翰·霍普金斯大学的Bhujwalla博士，约翰·霍普金斯大学，培训霍华德大学的分子成像原理和实践的教师。该计划有两个组成部分：协作研究组件和一个培训组成部分。该研究组件包括两个使用MRI和光学成像技术研究巨噬细胞在肿瘤轴承动物中的功能的项目。培训组成部分包括为学员组织研讨会，研讨会和实验室实习。