Partners Heart Failure Network

合作伙伴心力衰竭网络

基本信息

批准号：
7114616
负责人：
Lynne W Stevenson
金额：
$ 60.25万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2011-06-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Over 5 million people suffer from heart failure (HF) and 250,000 die annually, despite new medications and devices. Uniting strengths from diverse HF sites through the NHLBI, the National Heart Failure Network is vital to accelerate conceptual HF research and apply it to improve quality and length of life with HF. This proposal from Partners Heart Failure Program demonstrates dedication and expertise for improving HF outcomes, centered in HF clinics of Brigham and Women's and Massachusetts General Hospitals, enhanced by established collaboration with the Chabert HF site enrolling rural indigent patients in Louisiana. This represents 800 new patients and 5100 visits annually and 330 trial subjects the past 2 years. Expanded circles include 4 other Boston HF sites, 6 other Louisiana sites, and Partners Research and Education Program (PREP) supporting office-based clinical trials for 25 Boston community physicians. Objectives are: 1*) Facilitate establishment of an effective national network for research to improve outcomes in heart failure; with Two Major Aims: To contribute strong, diverse subject enrollment and to facilitate HF protocol design. Project A offers a template to assess the impact of regenerative therapy for late-stage HF, using catheter transfection of adeno-associated virus/SERCA2a protein. Project B provides a template for a 3-way trial of acute therapy in decompensated HF, comparing hormonal and mechanical to diuretic strategies for the cardiorenal syndrome. We advocate also the creation of two Vital Network Assets: a Parallel Advanced Registry to compare with VAD patients as the first Parallel Cohort analysis, and a Heart Failure DNA /Tissue Repository. 2*) Create the supportive matrix of senior, emerging, and junior investigators, with Training Core focus on rigorous didactics and diverse hands-on experiences to nurture the next generation of investigators. 3*) Enhance dissemination of network progress into community channels. Major strengths of this proposal are 1) breadth of expertise in clinical HF and relevant basic science; 2) enhanced value from institutional commitments to infrastructure at 3 sites and PREP; 3) real-time patient profiles for proven urban and rural enrollment; 4) focus on assessing strategies in advanced HF; 5) innovation into gene-based therapy for myocardial regeneration; and 6) successful precedent of inclusive collaboration for regional HF care and education and national NHLBI initiatives such as REMATCH, ESCAPE, and the National VAD Registry. (End of Abstract)

描述（由申请人提供）：尽管有新的药物和设备，但每年仍有超过 500 万人患有心力衰竭 (HF)，并有 25 万人死亡。国家心力衰竭网络通过 NHLBI 联合不同心力衰竭中心的优势，对于加速心力衰竭概念研究并将其应用于改善心力衰竭的质量和寿命至关重要。合作伙伴心力衰竭计划的这项提案展示了改善心力衰竭结果的奉献精神和专业知识，以布莱根妇女医院和马萨诸塞州总医院的心力衰竭诊所为中心，并通过与招募路易斯安那州农村贫困患者的 Chabert 心力衰竭站点建立的合作得到加强。这意味着过去 2 年每年有 800 名新患者、5100 名就诊者和 330 名试验对象。扩大的圈子包括其他 4 个波士顿 HF 站点、其他 6 个路易斯安那州站点，以及支持 25 名波士顿社区医生进行办公室临床试验的合作伙伴研究和教育计划 (PREP)。目标是： 1*) 促进建立有效的国家研究网络，以改善心力衰竭的结果；有两个主要目标：促进强大、多样化的学科招生并促进 HF 方案设计。项目 A 提供了一个模板，用于评估再生疗法对晚期心力衰竭的影响，使用腺相关病毒/SERCA2a 蛋白的导管转染。项目 B 提供了失代偿性心力衰竭急性治疗三路试验的模板，比较了治疗心肾综合征的激素、机械和利尿策略。我们还主张创建两个重要的网络资产：一个并行高级登记库，用于与 VAD 患者进行比较，作为第一个并行队列分析；以及一个心力衰竭 DNA/组织存储库。 2*) 创建由高级、新兴和初级研究人员组成的支持矩阵，核心培训侧重于严格的教学和多样化的实践经验，以培养下一代研究人员。 3*) 加强将网络进展传播到社区渠道。该提案的主要优势是 1) 临床心力衰竭和相关基础科学方面的专业知识广度； 2) 提高 3 个地点和 PREP 基础设施的机构承诺的价值； 3) 实时患者档案，用于经过验证的城乡入组情况； 4) 重点评估晚期心力衰竭的策略； 5）创新心肌再生基因疗法； 6) 地区性心力衰竭护理和教育以及国家 NHLBI 举措（如 REMATCH、ESCAPE 和国家 VAD 登记处）包容性合作的成功先例。（摘要完）