Models of Sensory Coding

感觉编码模型

• 批准号: 6970870
• 负责人: Michael Leon
• 金额: $ 26.83万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-08 至 2008-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6970870
• 关键词: behavior test; chemoreceptors; laboratory rat; model; odors; olfactions; olfactory lobe; olfactory stimulus; perception; respiratory epithelium; sensation; sensory mechanism

DESCRIPTION (provided by applicant): The goal of this proposal is to use direct experimental approaches to test the predictions of two models of olfactory coding. One model suggests that many low-specificity neural elements represent each odorant and the other model suggests that fewer, more specific olfactory receptors combine to convey information regarding multiple molecular features to characterize each odorant. The low-specificity model predicts no effect of any lesion on the coding of any odorant, while the combinatorial model predicts specific deficits with focal lesions. To test these predictions, we will determine the effects of focal olfactory bulb lesions on the recognition, discrimination, and detection of specific odorants. To that end, our laboratory has been studying the glomerular activity evoked by a large number of systematically differing odorants and we have characterized the response domains that combine to form their unique focal representations. Importantly, we have identified odorant pairs that evoke glomerular patterns differing only by a single response domain. Guided by the locations of these domains, we propose to lesion specific areas of focal glomerular activity of rats and we then propose to apply behavioral tests to reveal their resulting odor perceptions. These experiments should help us understand the mechanism by which the olfactory nervous system codes complex stimuli.

描述（由申请人提供）：该建议的目的是使用直接的实验方法来测试两种嗅觉编码模型的预测。一个模型表明，许多低特异性神经元素代表了每个气味，另一个模型表明，更少，更具体的嗅觉受体结合在一起，以传达有关多个分子特征的信息，以表征每个气味。低特异性模型预测任何病变对任何气味的编码没有影响，而组合模型则可以预测局灶性病变的特定缺陷。为了测试这些预测，我们将确定局灶性嗅球病变对特定气味剂的识别，歧视和检测的影响。为此，我们的实验室一直在研究大量系统不同的气味剂引起的肾小球活性，我们已经表征了组合形成其独特焦点表示的响应域。重要的是，我们已经确定了仅通过单个响应域而不同的肾小球模式的气味对。在这些结构域的位置的指导下，我们建议对大鼠的局灶性肾小球活性的特定区域，然后我们建议采用行为测试以揭示其产生的气味感知。这些实验应有助于我们了解嗅觉神经系统代码复杂刺激的机制。