The Social Neuroscience of Autism and Related Disorders

自闭症及相关疾病的社会神经科学

• 批准号: 6940829
• 负责人: FRED Robert Volkmar
• 金额: $ 171.97万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6940829
• 关键词: autism; clinical research; developmental disease /disorder; developmental psychology; social psychology

DESCRIPTION (provided by applicant): This application requests five years of support for a collaborative, multidisciplinary program of research on social neuroscience in autism and related disorders. This application, submitted as a STAART autism center, builds on important resources and research programs. It is concerned with increasing the understanding of the processes underlying the social-communicative and social-affective functioning of individuals with autism and related conditions. The focus of the grant is on integrating advances in neuroscience and genetics in understanding specific neurodevelopmental processes and risk factors and using this understanding in treatment studies. Objectives include characterization of visual scanning patterns of social stimuli, development of simple behavioral screening methods for young children at risk for autism, to determine whether young children with symptoms of autism display distinctive listening preferences as compared to developmentally delayed children, to assess the potential utility of computer assisted face training in autism with a goal of improving face perception skills and enhancing fusiform face area activity as seen on fMRI facial expression and normalization of visual scanning. In addition we propose to characterize the nature of anxiety disorders, particularly social anxiety disorder, in children and adolescents with PDD and to evaluate the effects of the selective serotonin reuptake inhibitor, fluvoxamine, in a randomized double-blind, placebo-controlled trial. Finally we plan to conduct a series of interrelated genetic studies with the overarching aim of identifying genetic mechanisms of social disability. Six projects and two core resources are proposed. Projects include: (I) Eye tracking studies of social engagement in infants and toddlers with autism, (II) Behavioral indices of joint attention in autism in young children, (III) Precursors to social communication in autism and related disorder, (IV) Molecular and family genetic studies of social phenotypes in autism, (V) Behavioral and neural plasticity in face recognition, and (VI) Fluvoxamine in the treatment of children and adolescents with social anxiety disorder.

描述（由申请人提供）：本申请要求对自闭症和相关疾病中社会神经科学的协作，多学科研究计划提供五年的支持。该应用程序以Staart自闭症中心的形式提交，以重要的资源和研究计划为基础。它关注的是对具有自闭症和相关条件的个体的社会交流和社会影响力的基础过程的理解。该赠款的重点是将神经科学和遗传学的进步整合到理解特定神经发育过程和危险因素以及在治疗研究中使用这种理解。 Objectives include characterization of visual scanning patterns of social stimuli, development of simple behavioral screening methods for young children at risk for autism, to determine whether young children with symptoms of autism display distinctive listening preferences as compared to developmentally delayed children, to assess the potential utility of computer assisted face training in autism with a goal of improving face perception skills and enhancing fusiform face area activity as seen on fMRI facial expression and normalization of visual scanning.此外，我们建议在患有PDD的儿童和青少年中表征焦虑症，尤其是社交焦虑症的性质，并在一项随机的双盲，安慰剂控制的试验中评估选择性5-羟色胺再摄取抑制剂Fluboxamine的影响。最后，我们计划进行一系列相互关联的遗传研究，其总体目的是确定社会残疾的遗传机制。提出了六个项目和两个核心资源。项目包括：（i）对婴儿和幼儿自闭症的社交参与研究的研究，（ii）自闭症儿童自闭症的共同注意的行为指标，（iii）自闭症和相关疾病中社会沟通的前体，（iv）分子和家庭遗传研究的社会遗传学研究在自闭症和神经塑料中（VI），（v）的塑料，（V），（v），（v）（VI）（VI）（VI）患有社交焦虑症。