Mechanisms of the Stress-Substance Use Disorder Relation

压力与物质使用障碍关系的机制

• 批准号: 7074035
• 负责人: Kevin Michael King
• 金额: $ 2.83万
• 依托单位: ARIZONA STATE UNIVERSITY-TEMPE CAMPUS
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7074035
• 关键词: adolescence (12-20); alcoholism /alcohol abuse; behavioral /social science research tag; child rearing; clinical research; conduct disorder; coping; family structure /dynamics; human data; impulsive behavior; interview; longitudinal human study; model design /development; parent offspring interaction; predoctoral investigator; psychological models; psychological stressor; questionnaires; substance abuse epidemiology; substance abuse related disorder; young adult human (21-34)

DESCRIPTION (provided by applicant): The proposed project is designed to test models of the mechanisms by which life stress during adolescence can lead to the development of substance use disorders. Most theoretical models of these mechanisms focus on stress-related increases in internalizing symptoms as being proximal to substance use; yet empirical findings have been mixed. An alternative pathway is proposed, where stressful life events produce elevations in conduct problems and externalizing symptoms, which subsequently leads to substance use disorders by young adulthood. Clarifying how stress during adolescence leads to substance use disorders in young adulthood informs etiological theories and helps to better specify prevention efforts. Aim 1 is to study the mediational roles of externalizing behaviors and internalizing symptoms in the relation between stress and substance use problems and dependence. Aim 2 is to study the moderational role of behavioral under control, supportive parenting and active coping on the above pathways from stress to substance dependence. Utilizing data from a longitudinal, high-risk sample of children of alcoholics and matched controls (N=454), this study is uniquely positioned to address the above issues.

描述（由申请人提供）： 该项目旨在测试青春期生活压力导致物质使用障碍发展的机制模型。这些机制的大多数理论模型都关注与压力相关的内化症状的增加，因为与物质使用最接近。然而实证结果却好坏参半。提出了另一种途径，即压力性生活事件会导致行为问题和外化症状加剧，从而导致成年早期出现药物滥用障碍。澄清青春期的压力如何导致成年早期的物质使用障碍，为病因学理论提供信息，并有助于更好地制定预防工作。目标 1 是研究外化行为和内化症状在压力与物质使用问题和依赖性之间的关系中的中介作用。目标 2 是研究控制行为、支持性养育和积极应对上述从压力到物质依赖的途径的调节作用。本研究利用来自酗酒者儿童和匹配对照 (N=454) 的纵向高风险样本的数据，具有独特的定位来解决上述问题。

项目成果

The relation between adolescent substance use and young adult internalizing symptoms: findings from a high-risk longitudinal sample.

青少年物质使用与年轻人内化症状之间的关系：来自高风险纵向样本的发现。

• DOI: 10.1037/0893-164x.21.1.97
• 发表时间: 2007
• 期刊: Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors
• 作者: Trim,RyanS;Meehan,BarbaraT;King,KevinM;Chassin,Laurie
• 通讯作者: Chassin,Laurie