Textpresso, an information retrieval and extraction system for biological literat

Textpresso，生物文学信息检索和提取系统

• 批准号: 7047977
• 负责人: PAUL Warren STERNBERG
• 金额: $ 30万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-23 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7047977
• 关键词: Caenorhabditis elegans; gene interaction; genes; genome; human; information retrieval; information systems; model

DESCRIPTION (provided by applicant): An information retrieval and extraction system that processes the full text of biological papers will be developed. A prototype system has been in operation at WormBase for over a year, used by C. elegans researchers as well as WormBase biological curators, and has recently been implemented for yeast at SGD. The system, called Textpresso, separates text into sentences, and labels words and phrases according to an ontology (an organized lexicon), and allows queries to be performed on a database of labeled sentences. The current ontology comprises 37 categories of terms, such as "gene," "regulation," "method," etc. Extraction of particular biological facts, such as gene-gene interactions, can be accelerated significantly by ontologies, with Textpresso automatically performing nearly as well as expert curators to identify sentences; in searches for two uniquely named genes and an interaction term, the ontology confers a threefold increase of search efficiency. This system will be further developed in three ways. First, the core system will be refined and altered to allow expansion to multiple domains of interest, e.g., model organisms, human disease. Simple modifications to the system and website functionality will be made, including synonym, search phrases, and case-sensitivity. A software package for local installation will be supported. The project team will maintain the Textpresso site (www.textpresso.org). which will include C. elegans and pilot systems, but software package will be available for installation of Textpresso at local sites, e.g., SGD, Flybase etc. Second, the ontology will be structured somewhat more deeply and lexica expanded for organism and field specific terms. Third, algorithms for information extraction will be implemented. One approach will be the implementation of similarity measures using categories (high level nodes) of the Textpresso ontology to reduce the dimensionality of associated vector spaces. A second approach will be the development of hidden Markov models to fill slots of a fact template based on the marked-up text. Information extracted will be presented to the user or expert curator. Public Description: The quality and pace of research depends upon rapid access to published information. This project will provide researchers with a search engine that rapidly gives them detailed, technical information they want by indexing the complete text of research articles.

描述（由申请人提供）： 处理生物论文全文的信息检索和提取系统将是 发达。原型系统已在 WormBase 运行一年多，由秀丽隐杆线虫使用 研究人员以及 WormBase 生物管理者，最近已在 SGD 中针对酵母实施了该技术。该系统称为 Textpresso，将文本分成句子，并根据本体（有组织的词典）标记单词和短语，并允许在标记句子的数据库上执行查询。目前的本体包含 37 类术语，例如“基因”、“调节”、“方法”等。本体可以显着加速特定生物事实的提取，例如基因-基因相互作用，而 Textpresso 几乎可以自动执行以及专家策展人来识别句子；在搜索两个唯一命名的基因和一个相互作用项时，本体使搜索效率提高了三倍。该系统将通过三个方面进一步发展。首先，核心系统将被完善和改变，以允许扩展到多个感兴趣的领域，例如模式生物、人类疾病。将对系统和网站功能进行简单的修改，包括同义词、搜索短语和区分大小写。将支持本地安装的软件包。项目团队将维护 Textpresso 网站 (www.textpresso.org)。其中将包括线虫和试点系统，但软件包将可用于在本地站点安装 Textpresso，例如 SGD、Flybase 等。其次，本体的结构将更加深入，词汇将针对生物体和领域进行扩展 具体条款。第三，将实施信息提取算法。一种方法是使用 Textpresso 本体的类别（高级节点）来实施相似性度量，以减少相关向量空间的维数。第二种方法是开发隐马尔可夫模型来填充基于标记文本的事实模板的槽位。提取的信息将呈现给用户或专家管理者。 公开描述：研究的质量和速度取决于对已发布信息的快速访问。该项目将为研究人员提供一个搜索引擎，通过索引研究文章的完整文本，快速为他们提供所需的详细技术信息。