ORWH: SCOR on Sex and Gender Factors Affecting Women's *

ORWH：影响女性的性和性别因素的 SCOR *

• 批准号: 6785924
• 负责人: JOHN O.L. DELANCEY
• 金额: $ 113.64万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6785924
• 关键词: clinical research; human subject; urinary incontinence; women' s health

DESCRIPTION (provided by applicant): This proposal seeks to improve care for the women who suffer the priority health conditions of urinary incontinence and pelvic organ prolapse. These problems arise due to women's unique role in giving birth and, therefore, occur much less often in men. Each year 3 million women deliver babies and 11 % of women need surgery for incontinence and prolapse. A lack of basic understanding of the mechanisms involved in these conditions and their implications for treatment impedes progress. We propose a SCOR to unite 5 existing multidisciplinary researchers and to add 4 new investigators to expedite development of new knowledge needed to improve treatment and prevention. Project 1, "Biomechanics" will test hypotheses concerning basic mechanisms of pelvic floor structure and function. It will analyze the mechanical arrangement and properties of the components of the pelvic floor as well as how vaginal birth damages their integrity. Project 2, "Clinical Mechanisms" will test continent and stress incontinent women to detect the unique failure of component parts that, singularly and in combinations, are associated with stress incontinence. Project 3, "Treatment Selection" will identify the effects of birth induced muscle damage in women with stress incontinence and from these data, build and test a model to determine which defects will predict success or failure of pelvic muscle treatment. Core A, Administrative/Human Subjects/Biostatistics core provides project support by recruiting subjects, compiling and analyzing data and protecting subject safety. In Core A, two study groups will be formed concerning 1) Gender Impact and 2) Basic Sciences Futures to discuss expanding the issues raised by this research. Core B, Measurement & Imaging will provide technical support for the projects along with integrated image analysis for 2 and 3 dimensional spatial data gathered across projects. This research will produce needed insights to help women with pelvic floor dysfunction.

描述（由申请人提供）： 该提案旨在改善对患有尿失禁和盆腔器官脱垂等主要健康问题的女性的护理。这些问题的出现是由于女性在生育方面的独特作用，因此在男性中发生的频率要低得多。每年有 300 万妇女分娩，其中 11% 的妇女因失禁和脱垂需要接受手术。对这些病症所涉及的机制及其对治疗的影响缺乏基本了解会阻碍进展。我们提议建立一个 SCOR，联合 5 名现有的多学科研究人员，并增加 4 名新的研究人员，以加快开发改善治疗和预防所需的新知识。项目 1“生物力学”将测试有关盆底结构和功能的基本机制的假设。它将分析盆底各组成部分的机械排列和特性，以及阴道分娩如何损害其完整性。项目2“临床机制”将测试失禁和压力失禁的女性，以检测与压力性失禁相关的单独或组合的部件的独特故障。项目 3“治疗选择”将确定出生引起的肌肉损伤对患有压力性尿失禁的女性的影响，并根据这些数据建立和测试模型，以确定哪些缺陷将预测盆腔肌肉治疗的成功或失败。核心A，行政/人类受试者/生物统计学核心通过招募受试者、编译和分析数据以及保护受试者安全来提供项目支持。在核心 A 中，将成立两个研究小组，分别涉及 1) 性别影响和 2) 基础科学未来，以讨论扩大本研究提出的问题。核心 B，测量与成像将为项目提供技术支持，并对跨项目收集的 2 维和 3 维空间数据进行集成图像分析。这项研究将为帮助患有盆底功能障碍的女性提供所需的见解。