Yoga for the Management of HIV-Metabolic Syndromes

瑜伽治疗艾滋病毒代谢综合症

• 批准号: 7140085
• 负责人: KEVIN E YARASHESKI
• 金额: $ 22.41万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7140085
• 关键词: AIDS therapy; HIV infections; adipose tissue; alternative medicine; antiAIDS agent; body composition; cardiovascular disorder risk; cardiovascular function; clinical research; fibrinolysis; glucose tolerance; glucose tolerance test; helper T lymphocyte; human subject; human therapy evaluation; inflammation; insulin sensitivity /resistance; leukocyte count; lifestyle; magnetic resonance imaging; medical complication; meditation; metabolic syndrome; oxygen consumption; patient oriented research; photon absorptiometry

DESCRIPTION (provided by applicant): The introduction of highly active antiretroviral therapy (HAART) has dramatically improved quality of life, and substantially reduced morbidity and mortality rates for people living with HIV. But, HIV-infection and HAART have been associated with a cluster of metabolic and anthropomorphic syndromes (HIV-metabolic syndrome; HIV+MS) that jeopardize long-term cardiovascular disease (CVD) risk profiles for people living with HIV. The cause of these complications is multifactorial. Few safe and effective traditional treatments (drugs, changing anti-HIV medications) have been identified. The ancient practice of a Yoga lifestyle has been re-popularized as a complementary, non-traditional treatment for metabolic, anthropomorphic, and cardiovascular disorders. Yoga provides integrated control and harmonious balance among eating habits, exercise, rest, breathing style, and the mind-body relationship through the practice of postures, muscle contraction, controlled breathing, and meditation. Holistic balance among physiologic processes provides relief from disease. We propose to objectively examine the safety and efficacy of a yoga lifestyle intervention in 26 women and 26 men infected with HIV, treated with HAART and experiencing metabolic syndromes that increase CVD risk. We hypothesize that a yoga lifestyle intervention will be safe and enhance (complement) the benefits of standard-of-care therapy for HIV+MS. Participants will be randomly assigned to continue standard-of-care therapy, or add a supervised yoga lifestyle intervention to standard-of-care therapy. Yoga lifestyle intervention will be taught and supervised by trained and experienced yoga instructors employed by Living By Design Inc., a St. Louis-based healthcare program that provides complementary and alternative rehabilitative therapies to people living with HIV (and other chronic disorders). Standardized and objective measurements of oral glucose tolerance, insulin sensitivity, serum lipid/lipoprotein levels, serum markers of fibrinolysis and inflammation, adipose tissue distribution, cardiovascular function and CVD risk will be quantified before and at the end of 4-months of therapy. Yoga lifestyle practices have not been objectively tested in the management of HIV+MS, and may offer an inexpensive, safe, effective and easy to adhere to alternative management strategy for a chronic infection with lifelong implications for CVD and other health risks.

描述（由申请人提供）：引入高度活跃的抗逆转录病毒疗法（HAART）已大大改善了生活质量，并大大降低了HIV患者的发病率和死亡率。但是，HIV感染和HAART与一群代谢和拟人化综合征（HIV代谢综合征； HIV+MS）有关，危害了患有HIV患者的长期心血管疾病（CVD）风险特征。这些并发症的原因是多因素。很少发现安全有效的传统治疗方法（药物，改变的抗HIV药物）。瑜伽生活方式的古老实践已被重新占据，作为一种互补的，非传统的治疗方法，用于代谢，拟人化和心血管疾病。瑜伽在饮食习惯，运动，休息，呼吸风格以及通过姿势，肌肉收缩，控制呼吸和冥想的实践中提供综合的控制和和谐平衡。生理过程之间的整体平衡可缓解疾病。我们建议客观地检查对26名女性和26名感染HIV的男性的瑜伽生活方式干预的安全性和功效，并接受了HAART治疗，并经历了增加CVD风险的代谢综合症。我们假设瑜伽生活方式干预将是安全的，并增强（补充）护理标准疗法对HIV+MS的好处。参与者将被随机分配以继续护理标准疗法，或在护理标准疗法中添加监督的瑜伽生活方式干预。 Live By Design Inc.雇用的训练有素且经验丰富的瑜伽教练将教授和监督瑜伽生活方式干预，这是一项总部位于圣路易斯的医疗保健计划，为艾滋病毒（和其他慢性疾病）提供补充和替代性康复治疗。口服葡萄糖耐量，胰岛素敏感性，血清脂质/脂蛋白水平，纤维蛋白溶解和炎症的血清标记，脂肪组织分布，心血管功能和CVD风险的标准化和客观测量。瑜伽生活方式实践尚未在HIV+MS的管理中进行客观测试，并且可能会提供廉价，安全，有效且易于遵守替代管理策略，以造成长期感染，对CVD和其他健康风险产生终生影响。