Novel Ceramic Microchannel Plates for Biomedical Imaging

用于生物医学成像的新型陶瓷微通道板

• 批准号: 6882551
• 负责人: Oleg G. Polyakov
• 金额: $ 19.97万
• 依托单位: SYNKERA TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-03 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6882551
• 关键词: Novel; Ceramic; Microchannel; Plates; Biomedical

DESCRIPTION (provided by applicant): Biomedical imaging, such as fluorescence microscopy and autoradiography, constantly raises the bar for sensitivity and spatial and temporal resolution of imaging detectors. Many advanced detectors used in biomedical imaging, including intensified CCD cameras, utilize microchannel plates (MCPs), which are solidstate electron multipliers, to intensify weak images. In comparison with other detection concepts, MCP's often provide the most favorable combination of sensitivity, spatial and temporal resolution. However, further improvements in performance/cost ratio of imaging detectors are hindered by the inherent limitations of conventional glass MCP technology. In this project, we propose to develop an alternative approach for fabricating MCPs from micromachined anodic alumina ceramics. The unique nanoscale morphology of this material enables its high aspect ratio micromachining, and provides opportunities for tailoring its properties. In Phase I we aim to demonstrate the feasibility of ceramic MCPs with biased channels, high resolution, high open area ratio and high temperature processing capabilities inaccessible with glass MCPs. The proposed approach could overcome the limitations of conventional technology and enable a new generation of image intensifies and detectors for biomedical imaging. Other applications include detectors for analytical and scientific instruments, research in astronomy and physics, as well as for night-vision devices for law enforcement, military and consumer markets.

描述（由申请人提供）： 生物医学成像（例如荧光显微镜和放射自显影）不断提高标准，以敏感性，空间和时间分辨率的探测器。生物医学成像中使用的许多高级探测器（包括加剧的CCD摄像机）使用的是固体元电子倍增器的微通道板（MCP）来加剧弱图像。与其他检测概念相比，MCP通常提供敏感性，空间和时间分辨率的最有利组合。但是，传统玻璃MCP技术的固有局限性阻碍了成像探测器的性能/成本比率的进一步提高。 在这个项目中，我们建议开发一种替代方法，用于制造微机械氧化铝陶瓷的MCP。该材料的独特纳米级形态可以使其高纵横比微加工，并为定制其特性提供了机会。在第一阶段，我们旨在证明具有偏置通道，高分辨率，高开放面积比和高温处理能力的陶瓷MCP的可行性，与玻璃MCP无法接近。所提出的方法可以克服常规技术的局限性，并使新一代的图像加强和检测生物医学成像。其他应用包括用于分析和科学工具的探测器，天文学和物理学的研究以及执法，军事和消费者市场的夜视设备。