Reflective multilayer X-ray optics for mammography

用于乳腺 X 线摄影的反射式多层 X 射线光学器件

基本信息

批准号：
6990332
负责人：
David L Windt
金额：
$ 10万
依托单位：
REFLECTIVE X-RAY OPTICS, LLC
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-01 至 2007-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6990332
关键词：
Reflective multilayer ray optics mammography

项目摘要

DESCRIPTION (provided by applicant): A new class of X-ray optic will be developed that can be used with conventional mammography X-ray tubes, in place of K-edge filters, in order to produce a mono-energetic diagnostic X-ray beam. The X-ray optic is based on proven, currently-available technology, comprising planar reflective multilayer X-ray mirrors that act as extremely efficient energy filters. The multilayer mirror coatings are designed to have a narrow energy bandpass, and can be tuned arbitrarily to specific X-ray energies, for example the Mo Ka line at 17.5 keV, the Rh Ka line at 20.2 keV, or higher energies as desired. The mirror reflection efficiency at the target energy is high, while the reflectance outside of the approximately 0.5 keV bandpass is orders of magnitude smaller. The proposed X-ray optic when used in place of K-edge filters, either in a scanning slot or full-field geometry, and in combination with conventional mammography X-ray tubes, will result in significant increases in both signal contrast and signal-to-noise ratio, while simultaneously reducing patient dose, especially in the case of thicker, more dense breasts, and without any increase in exposure time or degradation of spatial resolution. These expected performance enhancements represent important clinical benefits that will facilitate more accurate and sensitive detection of small lesions, thereby improving the health of a substantional portion of the human population. The specific aims of this Phase I proposal are to fabricate and test a simple, small-field protype X-ray optic of the type just described, and measure the X-ray spectrum it produces in combination with a conventional mammography X-ray tube. Meeting these objectives will demonstrate the technical feasibility of the proposed approach. The long-term (Phases II and III) objectives of this program include a comprehensive experimental study of the clinical performance of these optics, and the development of full-field X-ray optics that can be cost-effectively mass-produced and incorporated into commercial mammography systems.

描述（由申请人提供）：将开发一类新的X射线光学件，可与常规乳房X线摄影X射线管一起使用，代替K边缘过滤器，以产生单能诊断X射线束。 X射线视频基于经过验证的当前可用技术，其中包括平面反射性多层X射线镜，可作为极有效的能量过滤器。多层镜涂层设计为具有狭窄的能量带通道，可以任意调整到特定的X射线能量，例如17.5 KeV的Mo Ka线，20.2 KeV的RH KA线，或根据需要的更高的能量。目标能量的镜像反射效率很高，而大约0.5 keV带通的反射率较小。在扫描插槽或全场几何形状以及与常规的乳房X线X射线X射线管结合使用时，提出的X射线光学在代替K边缘过滤器时，将显着增加信号对比度和信号性比率，同时减少患者剂量，尤其是在较高的情况下，且没有任何较高的乳房，而不需要更浓密的乳房。这些预期的绩效增强能力代表了重要的临床益处，将有助于对小病变进行更准确和敏感的检测，从而改善人口中大部分人口的健康状况。该阶段I提案的特定目的是制造和测试刚刚描述的类型的简单的小型小场X射线X射线光学，并测量其与常规乳房X线摄影X射线管结合产生的X射线光谱。实现这些目标将证明拟议方法的技术可行性。该计划的长期目标（II和III阶段）包括对这些光学临床性能的全面实验研究，以及可以成本效率地批量生产并将其纳入商业乳房X线摄影系统的全景X射线光学器件的发展。