Multilayer X-ray Optics for Mammography

用于乳腺 X 线摄影的多层 X 射线光学器件

• 批准号: 7391467
• 负责人: David L Windt
• 金额: $ 37.48万
• 依托单位: REFLECTIVE X-RAY OPTICS, LLC
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391467
• 关键词: Affect; Anodes; Breast; Breast Cancer Detection; Class; Classification; Clinical; Coupled; Detection; Development; Diagnostic; Diagnostic radiologic examination; Digital Mammography; Disease; Dose; Female; Future; Health; Histocompatibility Testing; Human; Image; Imaging Techniques; Lead; Lesion; Mammography; Medical; Mono-S; Noise; Optics; Patients; Performance; Phase; Population; Range; Relative (related person); Resolution; Roentgen Rays; Scanning; Screening procedure; Shapes; Signal Transduction; Source; System; Techniques; Technology; Thick; Time; Tissues; Tube; absorption; analog; base; design; evaluation/testing; improved; metrology; neoplastic; novel; programs; prototype; research and development; research study; simulation; success; voltage

DESCRIPTION (provided by applicant): A new class of X-ray optic will be developed that can be used with conventional mammography X-ray tubes, in place of K-edge filters, in order to produce a mono-energetic X-ray beam. The X-ray optic is based on proven, currently-available technology, comprising planar reflective multilayer X-ray mirrors that act as extremely efficient energy filters. The multilayer mirror coatings are designed to have a narrow energy bandpass, and can be tuned arbitrarily during fabrication to specific X-ray energies. The mirror reflectance at the target energy is high, while the reflectance outside of the narrow bandpass is orders of magnitude smaller. The X-ray optic to be developed, when used in place of K-edge filters either in a scanning slot or full-field geometry, and in combination with conventional mammography X-ray tubes, will result in a significant improvement in image quality while simultaneously reducing patient dose, especially in the case of thicker, more dense breasts, and without any increase in exposure time or degradation of spatial resolution. These expected performance enhancements represent important clinical benefits that will facilitate more accurate and sensitive detection of small lesions, thereby improving the health of a substantial portion of the human population. Building upon the successful demonstration of the technical feasibility of this technology achieved during Phase I, this technology will be fully developed during Phase II for incorporation into commercial analog or digital mammography machines.Project Narrative We plan to develop a new class of X-ray optic for mammography that will result in a significant improvement in image quality while simultaneously reducing patient dose. These expected performance enhancements represent important clinical benefits that will facilitate more accurate and sensitive detection of small lesions, thereby improving the health of a substantial portion of the human population. We plan to incorporate the technology we develop into commercial analog and/or digital mammography machines.

描述（由申请人提供）：将开发一类新的X射线光学件，可与常规乳房X线摄影X射线管一起使用，代替K边缘过滤器，以产生单能X射线梁。 X射线视频基于经过验证的当前可用技术，其中包括平面反射性多层X射线镜，可作为极有效的能量过滤器。多层镜涂层设计为具有狭窄的能量带通道，可以在制造过程中任意调整到特定的X射线能量。目标能量的镜像反射率很高，而窄带通道外部的反射率较小。当在扫描插槽或全场几何形状中使用K-Edge滤波器，并与常规乳房X线X射线管结合使用时，将要开发的X射线视觉元件将导致图像质量的显着提高，同时减少患者剂量，尤其是在膨胀，更浓密的情况下，并且在没有任何时间内的情况下，尤其是在曝光量增加的情况下。这些预期的绩效增强能力代表了重要的临床益处，将促进对小病变的更准确和敏感的检测，从而改善了大部分人口的健康状况。基于成功证明在第一阶段实现的这项技术的技术可行性的基础上，该技术将在第二阶段中全面开发，以纳入商业模拟或数字乳房X线摄影机。 我们计划开发一类新的X射线视觉乳房X线摄影，这将导致图像质量的显着改善，同时减少患者剂量。这些预期的绩效增强能力代表了重要的临床益处，将促进对小病变的更准确和敏感的检测，从而改善了大部分人口的健康状况。我们计划将我们开发的技术纳入商业模拟和/或数字乳房X线摄影机。