Impact of Life Stress on HIV Treatment Adherence

生活压力对艾滋病毒治疗依从性的影响

• 批准号: 7127670
• 负责人: KATHRYN A BOTTONARI
• 金额: $ 3.06万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-19 至 2007-10-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127670
• 关键词: AIDS; AIDS therapy; behavioral /social science research tag; clinical research; coping; depression; health behavior; human subject; injury /disease stressor; interview; personality; physiologic stressor; predoctoral investigator; psychological stressor; quality of life; self care; social psychology; socioenvironment; therapy compliance

DESCRIPTION (provided by applicant): Individuals infected with the Human Immunodeficiency Virus (HIV) are now living longer lives as a result of treatment with antiretroviral therapies. Unfortunately, many individuals have difficulty maintaining adequate compliance with their HIV treatment regimens. As life stress has toxic effects on health, well-being, and self- care behaviors, it is hypothesized that life stress also contributes to problematic adherence. This 3-month prospective investigation seeks to examine the impact of life stress on adherence to HIV treatment regimens. Past theory and research suggests that coping plays a key role in how individuals respond to life stressors, and therefore, it is expected that the impact of life stress on treatment adherence will depend on coping style. Further, elevated depressive symptoms are associated with dysfunctional coping, and therefore, it is expected that depression will amplify the effects of stress on adherence. In summary, I will test a model positing that maladaptive coping style (including substance use and social withdrawal) mediates the association between life stress and adherence, particularly among more severely depressed individuals. Results will aid treatment providers in constructing interventions to increase treatment adherence.

描述（由申请人提供）：由于抗逆转录病毒疗法的治疗，感染人类免疫缺陷病毒（HIV）的个体现在寿命更长。不幸的是，许多人难以充分遵守其艾滋病毒治疗方案。由于生活压力对健康、福祉和自我保健行为具有毒害作用，因此假设生活压力也会导致依从性问题。这项为期 3 个月的前瞻性调查旨在探讨生活压力对艾滋病毒治疗方案依从性的影响。过去的理论和研究表明，应对方式在个体如何应对生活压力源方面发挥着关键作用，因此，预计生活压力对治疗依从性的影响将取决于应对方式。此外，抑郁症状加重与应对功能失调有关，因此，预计抑郁会放大压力对依从性的影响。总之，我将测试一个模型，假设适应不良的应对方式（包括物质使用和社交退缩）介导了生活压力和依从性之间的关联，特别是在抑郁较严重的个体中。结果将帮助治疗提供者制定干预措施以提高治疗依从性。