Recognition Memory after Mild Traumatic Brain Injury

轻度脑外伤后的识别记忆

• 批准号: 7157862
• 负责人: Hala J Darwish
• 金额: $ 5.05万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7157862
• 关键词: behavior test; behavioral /social science research tag; brain injury; form /pattern perception; laboratory rat; memory; memory disorders; neural information processing; predoctoral investigator; sequential perception; temporal lobe /cortex; trauma; visual perception

DESCRIPTION (provided by applicant): Approximately 300,000 Americans sustain a Mild Traumatic Brain Injury (MTBI) each year. Although the injury is classified as mild, the brain is indeed injured. MTBI results in subtle neuro-anatomical and neuro- psychological deficits that may lead to disrupted lifestyle. Memory deficits, including recognition and temporal order abilities, have been reported after MTBI. We know little about the characteristics and trajectory of impaired recognition memory after MTBI. The aim of this application is to use an animal model to systematically explore recognition memory following MTBI. The intent is to characterize behaviors and examine brain tissue histologically. Such work is not yet possible in human. The exploration of the brain regions associated with recognition and temporal order memory deficits after MTBI, such as the hippocampus, the parahippocampus and the perirhinal cortex, will help determine some of the possible conditions under which behaviors resulting from recognition deficits are observed. Better understanding of recognition memory deficits after MTBI and the conditions under which they are observed will guide the development of targeted nursing therapies.

描述（由申请人提供）：每年大约有 300,000 名美国人遭受轻度创伤性脑损伤 (MTBI)。虽然伤势属于轻伤，但大脑确实受伤了。 MTBI 会导致微妙的神经解剖学和神经心理缺陷，可能导致生活方式紊乱。 MTBI 后报告了记忆缺陷，包括识别和时间顺序能力。我们对 MTBI 后识别记忆受损的特征和轨迹知之甚少。本应用的目的是使用动物模型系统地探索 MTBI 后的识别记忆。目的是表征行为并从组织学角度检查脑组织。这样的工作在人类中尚不可能实现。对 MTBI 后与识别和时间顺序记忆缺陷相关的大脑区域（例如海马体、海马旁回和嗅周皮层）的探索将有助于确定观察到识别缺陷导致的行为的一些可能条件。更好地了解 MTBI 后的识别记忆缺陷以及观察这些缺陷的条件将指导有针对性的护理疗法的开发。