Maternal physiological factors influencing labor length

影响产程长度的产妇生理因素

• 批准号: 7156819
• 负责人: JEREMY L NEAL
• 金额: $ 3.36万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-01-03 至 2009-01-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7156819
• 关键词: birth; clinical research; fatigue; sectioning

DESCRIPTION (provided by applicant): The World Health Organization advises that no region in the world is justified in having a C-section rate >10- 15%. In 2004, the U.S. had a total rate of 29.1% and a primary rate of 20.6%. As these rates rise, so does the morbidity and mortality risk imposed on mothers and neonates. Dystocia is the greatest contributor to C- sections accounting for nearly 50% of all C-sections performed on nulliparous women. It is known that [1] abnormalities of uterine power are, by far, the greatest contributor to dystocia and [2] dystocia-afflicted labors that progress to a vaginal delivery have a much greater likelihood of increased labor lengths. This suggests uterine fatigue may be involved. This study will investigate factors that may: [1] contribute to increased labor length by increasing uterine fatigue; [2] indicate energy availability is inadequate; [3] indicate myometrial cell- damage has occurred. Specific aims will identify the relationships between labor length and maternal: [1] oxygen carrying capacity; [2] hydration status; [3] nutritive substrate status and; [4] myometrial cell-damage. A convenience sample of low-risk, nulliparous women in labor (n = 73) at term (greater than or equal to 37 - less than or equal to 42 wks) will be studied. Identifying events/conditions that contribute to increased labor length via effects on uterine fatigue may unveil factors contributing to labor dystocia. Results may offer support to alternative labor management strategies.

描述（由申请人提供）：世界卫生组织建议，世界上没有任何地区的剖腹产率 >10-15% 是合理的。 2004年，美国的总入学率为29.1%，初等入学率为20.6%。随着这些比率的上升，母亲和新生儿的发病和死亡风险也随之增加。难产是剖腹产的最大原因，占所有未产妇剖腹产的近 50%。众所周知，[1] 子宫功率异常是迄今为止导致难产的最大因素，[2] 受难产困扰的产程进展为阴道分娩时，产程长度增加的可能性更大。这表明可能涉及子宫疲劳。这项研究将调查可能的因素： [1] 通过增加子宫疲劳而导致产程延长； [2] 表明能源供应不足； [3]表明子宫肌细胞已发生损伤。具体目标将确定产程长度与产妇之间的关系：[1] 携氧能力； [2] 水合状态； [3]营养底物状况和； [4] 子宫肌细胞损伤。将研究低风险、足月（大于或等于 37 周 - 小于或等于 42 周）的未产妇（n = 73）的方便样本。识别通过影响子宫疲劳而导致产程延长的事件/条件可能会揭示导致难产的因素。结果可能为替代性劳动力管理策略提供支持。