Neurophysiologic basis and specificity of fMRI

fMRI 的神经生理学基础和特异性

• 批准号: 6999386
• 负责人: Michael Lawrence Lipton
• 金额: $ 16.87万
• 依托单位: MONTEFIORE MEDICAL CENTER (BRONX, NY)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-12-11 至 2007-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6999386
• 关键词: Macaca; action potentials; bioimaging /biomedical imaging; brain electrical activity; electrodes; electrophysiology; fingers; functional magnetic resonance imaging; histology; noninvasive diagnosis; somesthetic sensory cortex; touch

DESCRIPTION (provided by applicant): Noninvasive assessment of brain function using blood-oxygen-level-dependent (BOLD) fMRI has gained enthusiastic and widespread acceptance among cognitive neuroscience investigators. This indirect approach to interrogating neural activity is based on work originating with Sherrington: the understanding that hemodynamic changes are coupled to neuronal activity. However, the extent to which the BOLD effect truly reflects and accurately localizes underlying neuronal activity remains unclear. The overall aim of this project is to optimize localization and characterization of brain activity, using noninvasive functional magnetic imaging (fMRI) and to assess the relationship of the optimized fMRI measurement to neuronal electrical activity. Ultimately these optimized measures will be implemented in humans for planning prior to surgical resection. The specific aims are: 1. Investigate differences in the discrete somatotopic representation of individual digits of the hand in primary somatosensory cortex (Area 3b) using BOLD and CBF-based fMRI to determine the relative specificity of the BOLD and CBF measurements. 2. Investigate differential activation of cortical layers in S1 using this somatosensory paradigm and CBF versus BOLD acquisition methods. 3. Identify Neural Correlates of BOLD-fMRI using multi-electrode survey of brain regions within monkey S1 exhibiting BOLD and CBF activation in response.

描述（由申请人提供）：使用血氧级依赖性（BOLD）fMRI对大脑功能的无创评估已在认知神经科学研究者中获得了热情和广泛的接受。这种间接询问神经活动的方法是基于源自Sherrington的工作：了解血液动力学变化与神经元活性耦合的理解。但是，大胆效应真正反映和准确定位的基本神经元活性的程度尚不清楚。该项目的总体目的是使用非侵入性功能磁成像（fMRI）优化大脑活动的定位和表征，并评估优化的fMRI测量与神经元电活动的关系。最终，这些优化的措施将在人类中实施，以便在手术切除之前进行计划。具体目的是：1。使用基于BOLD和CBF的FMRI确定BOLD和CBF测量值的相对特异性，研究原发性体感皮层（区域3B）的离散体体数字的差异。 2。使用这种体感范式和CBF与大胆的采集方法研究S1中皮层层的差异激活。 3。使用对猴子S1内大脑区域的多电极调查来确定BOLD-FMRI的神经相关性，这些调查表现出BOLD和CBF激活。