Neurophysiologic basis and specificity of fMRI

fMRI 的神经生理学基础和特异性

基本信息

批准号：
7189125
负责人：
Michael Lawrence Lipton
金额：
$ 17.06万
依托单位：
MONTEFIORE MEDICAL CENTER (BRONX, NY)
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-12-11 至 2007-11-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7189125
关键词：
Action Potentials Anesthetics Area Body Surface Area Brain Brain region Carbon Dioxide Cardiac Chromosome Pairing Core-Binding Factor Coupled Cutaneous Depth Detection Digit structure Electrodes Excision Exhibits Functional Magnetic Resonance Imaging Hand Head Human Image Image Analysis Individual Interneurons Life Localized Macaca Magnetism Maps Measurement Measures Mediating Methods Microcirculatory Bed Modeling Monkeys Morphologic artifacts Motion Movement Neurons Operative Surgical Procedures Physiological Primates Protocols documentation Rate Relative (related person)Research Personnel Resolution Sensory Signal Transduction Site Somatosensory Cortex Source Specificity Surface Surveys Synapses System Testing Thalamic structure Tissues Variant Venous Work base blood oxygen level dependent cognitive neuroscience density hemodynamics indexing magnetic field programs receptive field relating to nervous system research study response sample fixation sensory cortex somatosensory vascular bed

项目摘要

DESCRIPTION (provided by applicant): Noninvasive assessment of brain function using blood-oxygen-level-dependent (BOLD) fMRI has gained enthusiastic and widespread acceptance among cognitive neuroscience investigators. This indirect approach to interrogating neural activity is based on work originating with Sherrington: the understanding that hemodynamic changes are coupled to neuronal activity. However, the extent to which the BOLD effect truly reflects and accurately localizes underlying neuronal activity remains unclear. The overall aim of this project is to optimize localization and characterization of brain activity, using noninvasive functional magnetic imaging (fMRI) and to assess the relationship of the optimized fMRI measurement to neuronal electrical activity. Ultimately these optimized measures will be implemented in humans for planning prior to surgical resection. The specific aims are: 1. Investigate differences in the discrete somatotopic representation of individual digits of the hand in primary somatosensory cortex (Area 3b) using BOLD and CBF-based fMRI to determine the relative specificity of the BOLD and CBF measurements. 2. Investigate differential activation of cortical layers in S1 using this somatosensory paradigm and CBF versus BOLD acquisition methods. 3. Identify Neural Correlates of BOLD-fMRI using multi-electrode survey of brain regions within monkey S1 exhibiting BOLD and CBF activation in response.

描述（由申请人提供）：使用血氧水平依赖性（BOLD）功能磁共振成像对脑功能进行无创评估已获得认知神经科学研究人员的热情和广泛接受。这种询问神经活动的间接方法是基于 Sherrington 的工作：血流动力学变化与神经元活动相关的理解。然而，BOLD 效应在多大程度上真正反映并准确定位潜在的神经元活动仍不清楚。该项目的总体目标是使用无创功能磁成像 (fMRI) 优化大脑活动的定位和表征，并评估优化的 fMRI 测量与神经元电活动的关系。最终，这些优化的措施将在人类身上实施，以便在手术切除之前进行规划。具体目标是： 1. 使用 BOLD 和基于 CBF 的 fMRI 研究初级体感皮层（区域 3b）中手部各个手指离散体位表征的差异，以确定 BOLD 和 CBF 测量的相对特异性。 2. 使用这种体感范例和 CBF 与 BOLD 采集方法研究 S1 中皮质层的差异激活。 3. 使用多电极调查猴子 S1 内表现出 BOLD 和 CBF 激活反应的大脑区域，识别 BOLD-fMRI 的神经相关性。