Developing behavioural methods to assess pain in horses

开发评估马疼痛的行为方法

• 批准号: 2686844
• 金额: --
• 依托单位: University of Edinburgh
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2025
• 资助国家: 英国
• 起止时间: 2025 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2686844
• 关键词: Developing; behavioural; methods; assess; pain

As of 1st July 2022, Olivia Curry commenced a new PhD project Developing behavioural methods to assess pain in horses under the Supervision of Cathy Dwyer, Juliet Duncan and Gemma Pearson.This studentshi project will look at the causes, risk factors and diagnoses associated with Equine Grass Sickness (EGS), adopting an inter-disciplinary collaborative approach. Both biological and environmental factors will be investigated, with the student having the opportunity to review all available research and using a multi-disciplinary approach, identify gaps in knowledge and undertake relevant research strands to elucidate causal agents and risk factors. Previous research has looked at individual potential causal agents and the lack of success so far in identifying a causative agent suggests it may be multifactorial.The main strands of this research project will include:- Developing a relevant and novel in vitro system comprising 3D gut enteroid cultures from horses to enable the study of the early host-pathogen interactions following challenge of the in vitro cultures with some of the leading candidate causal agents that may be involved in equine grass sickness. - Investigating the use of saliva as a non-invasive test in horses to detect host immune responses to a range of candidate antigens from potential causal agents that may play a role in inducing equine grass sickness. - Samples for the project will be collected in longitudinal studies in selected areas where grass sickness has been prevalent in recent years.- Establishment of a national biobank and database, including questionnaire development, collaborating with vets, horse owners and researchers, to collect biological and environmental samples from EGS cases and controls.

截至2022年7月1日，奥利维亚·库里（Olivia Curry）开始了一个新的博士项目，开发了行为方法，以评估凯茜·德威尔（Cathy Dwyer），朱丽叶（Juliet Duncan）和杰玛·皮尔森（Gemma Pearson）的监督下的马匹疼痛。这项学生会将研究与马疗法（EGS）相关的原因，风险因素和诊断，采用与学科的合作方法。将研究生物学和环境因素，学生有机会审查所有可用的研究并采用多学科方法，确定知识的差距并进行相关的研究链以阐明因果因素和风险因素。先前的研究已经研究了个体的潜在因果因素，到目前为止缺乏成功，在确定因果毒剂方面可能是多因素的。该研究项目的主要链将包括： - - 开发一种相关和新颖的体外系统，该系统包括3D肠肠内培养物，从骑马中构成了与早期的培养物相互作用的研究，以促进某些领先的培养物，以供一些领先的培养物进行研究，从而涉及某些领先的培养物，这些培养物的经验是在体外的培养物，这些培养物的经验是在体外的范围。疾病。 - 研究在马匹中使用唾液作为一种非侵入性测试，以检测可能在诱导马草疾病中起作用的潜在因果毒剂的一系列候选抗原的免疫反应。 - 该项目的样本将在近年来普遍存在的草疾病的纵向研究中收集。-建立一个国家生物库和数据库，包括问卷开发，与兽医，马拥有者和研究人员合作，以收集来自EGS病例和控制的生物学和环境样品。