Neural Mechanisms of Compulsive Hoarding

强迫性囤积的神经机制

基本信息

批准号：
7101532
负责人：
DAVID F TOLIN
金额：
$ 26.55万
依托单位：
HARTFORD HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-05-01 至 2010-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Compulsive hoarding is a common, debilitating, and treatment-resistant syndrome characterized by excessive acquisition, difficulty discarding, and excessive clutter leading to marked impairment and health risk. Although a cognitive-behavioral model of compulsive hoarding is emerging, to date few studies have examined the neurobiological aspects of this syndrome. The aims of the proposed study are: (1) To extend our previous findings suggesting a dysfunction in action monitoring for compulsive hoarding, in which the anterior cingulate cortex (ACC) produces false error signals when making decisions about discarding possessions. This prediction, in keeping with the emerging cognitive-behavioral model of hoarding, is based on the theory that these false error signals are experienced as the feeling that things are "not just right," leading to increased anxiety, inability to resolve the decision-making process, and ultimately a decreased likelihood of discarding. (2) To extend our previous findings suggesting that compulsive hoarding is associated with hyperactivity in frontal-striatal circuits during symptom provocation. The cognitive-behavioral model also suggests that hoarders experience an exaggerated sense of attachment to their possessions. When making decisions about discarding possessions, this attachment increases hoarders' perceived risk of making a wrong decision and thus leads to avoidance of decision-making. Our pilot data suggest that this excessive attachment may be related to activation in orbitofrontal cortex (OFC). (3) To clarify the relationship between ACC action-monitoring dysfunction and phenomenological indices of hoarding such as "not just right experiences" and emotional attachment to objects. In order to validate observed activation patterns, we will relate neural activation to subjective and behavioral indices of decision-making deficits. (4) To examine functional connectivity in compulsive hoarding and control participants during a novel and evocative hoarding-related symptom provocation task. We will use cutting-edge data analytic procedures to examine patterns of interrelated neural activation as well as the time course of activation across the decision making process.

描述（由申请人提供）：强迫性ho积是一种常见，使人衰弱和耐药综合征，其特征是获得过多的收购，难以丢弃和过度混乱，导致明显的损害和健康风险。尽管强迫性ho积的认知行为模型正在出现，但迄今为止，很少有研究检查了该综合征的神经生物学方面。拟议的研究的目的是：（1）扩展我们以前的发现，表明在动作监测强迫性ho积的动作障碍中，前扣带回皮层（ACC）在做出有关丢弃财产的决策时会产生错误的错误信号。这种预测与新兴的ho积认知行为模型保持一致，它基于这样的理论：这些错误的错误信号是因为感觉不仅是正确的，因此导致焦虑增加，无法解决决策过程，并最终无法解决脱节的可能性。（2）扩展了我们以前的发现，表明在症状挑衅期间，强迫性ho积与额叶纹状体电路的多动症有关。认知行为模型还表明，ho积者对自己的财产有夸张的依恋感。在决定丢弃财产的决定时，这种依恋会增加ho积者做出错误决定的风险，从而导致避免决策。我们的试点数据表明，这种过度的依恋可能与Orbitrontal皮层（OFC）中的激活有关。（3）阐明ACC动作监测功能障碍与ho积的现象学指标之间的关系，例如“不仅仅是正确的经验”和对物体的情感依恋。为了验证观察到的激活模式，我们将将神经激活与决策缺陷的主观和行为指数联系起来。（4）在新颖且令人回味的与ho积相关的症状挑衅任务中检查强迫ho积和控制参与者中的功能连通性。我们将使用尖端的数据分析程序来检查相互关联的神经激活的模式以及整个决策过程中激活的时间过程。