Early Intervention for Childhood Hypermetropia

儿童远视的早期干预

• 批准号: 7124700
• 负责人: Kristina Tarczy-Hornoch
• 金额: $ 18.82万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7124700
• 关键词: amblyopia; child physical development; clinical research; clinical trials; disease /disorder prevention /control; early diagnosis; eye accommodation; eye coordination disorder; eye disorder diagnosis; eye refraction disorder; eye refractometry; human subject; human therapy evaluation; infant human (0-1 year); optic disk; patient oriented research; preschool child (1-5); prognosis; vision aid; visual perception

DESCRIPTION (provided by applicant): This proposal is for a 5 year research career development plan for Kristina Tarczy-Hornoch, MD, DPhil, to support her transition from a laboratory research background toward an independent patient-oriented research career in pediatric ophthalmology. The development plan consists of (1) structured training: coursework in epidemiology, biostatistics and public health leading to an MPH degree, courses and seminars in research ethics and career development, seminars in ophthalmology and preventive medicine, and practical exposure to clinical research through the research activities of mentors and consultants; (2) mentored clinical research. Her mentoring committee consists of Rohit Varma, MD, MPH, Stanley Azen, PhD, and Mark Borchert, MD, with consultation support from Joseph Miller, MD, MPH and Rowan Candy, MCOptom, PhD. The mentored research study will address a long-standing controversy over the value of early spectacle treatment for young children with hypermetropia, to prevent strabismus and amblyopia. The aims are to recruit 100 children 6-24 months of age with isolated hypermetropia, and conduct a randomized, controlled trial of spectacle treatment, describing the incidence of strabismus/amblyopia by age 3.5 years, as well as visual acuity outcomes, optic disc size, emmetropization, and the prognostic value of accommodative lag. The University of Southern California (USC) strongly supports Dr. Tarczy-Hornoch, and the environment at USC and Childrens Hospital Los Angeles is well-suited to her career development plan. The proposal would lead to (1) her establishment as an independent clinical investigator, and (2) completion of a study addressing a question with important public health implications, likely leading to a large multi-site randomized clinical trial under the auspices of the Pediatric Eye Disease Investigator Group.

描述（由申请人提供）：该提案是针对Kristina Tarczy-Hornoch，医学博士，DPHIL的5年研究职业发展计划，以支持她从实验室研究背景过渡到小儿眼科中独立的以患者为导向的研究职业。该开发计划包括（1）结构化培训：流行病学，生物统计学和公共卫生的课程工作，导致MPH学位，研究伦理学和职业发展的课程和研讨会，眼科和预防医学的研讨会，以及通过导师和顾问的研究活动通过临床研究的实际暴露于临床研究； （2）指导的临床研究。她的指导委员会由医学博士Rohit Varma，MPH，Stanley Azen博士和医学博士Mark Borchert组成。这项指导的研究将解决关于早期奇观治疗对高超度儿童的价值的长期争议，以防止斜视和弱视。其目的是招募100名6-24个月大的儿童，患有孤立的超极性，并进行了奇观治疗的随机，对照试验，描述了3.5岁时斜视/弱视的发生率，以及视觉敏锐度的结果，选择性粘贴大小，emmetropization usmetropization usmetropization usmetropization usmetropization usmblopia usmblyopia。南加州大学（USC）强烈支持Tarczy-Hornoch博士，南加州大学和洛杉矶儿童医院的环境非常适合她的职业发展计划。该提案将导致（1）她作为独立临床研究者的建立，以及（2）完成一项针对重要公共卫生影响的问题的研究，可能导致在小儿眼病研究员组的主持下进行大型多站点随机临床试验。