Assessment of Penile Autonomic Innervation

阴茎自主神经支配的评估

• 批准号: 7028153
• 负责人: Claire C Yang
• 金额: $ 15.55万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-15 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7028153
• 关键词: central nervous system disorders; clinical research; diagnosis design /evaluation; efferent nerve; electrophysiology; evoked potentials; human subject; impotence; innervation; male; nerve injury; neuropathology; patient oriented research; penis; penis erection; peripheral nervous system disorders; questionnaires; reproductive system disorder diagnosis; sympathetic nervous system

DESCRIPTION (provided by applicant): . Assessment of Penile Autonomic Innervation The cavernous nerves provide the autonomic innervation of the penis and are crucial to healthy erectile function. However, cavernous neuropathy in humans is not currently tested by any widely accepted method The main objective of this proposal is to investigate cavernous nerve function using electrophysiologic techniques. Our hypothesis is that evoked electrical activity in the corpus cavernosum, known as evoked cavernous activity, is a measure of the integrity of penile innervation by the cavernous nerves. The specific aims in this proposal are: 1. To measure evoked cavernous activity following activation of the sympathetic nervous system in healthy, potent men, and 2. To measure evoked cavernous activity following activation of the sympathetic nervous system in men with erectile dysfunction due to cavernous nerve injury. Cavernous nerve integrity will be determined by recording the electrical activity manifested in the corpus cavernosum using standard clinical electrophysiological equipment modified for use in the male genitalia. The presence of electrical impulses, stimulated by activation of sympathetic fibers, will indicate the integrity of corporal innervation by the cavernous nerves. We will be corroborating measures of erectile function with the electrophysiologic data. These studies are prompted by the significant occurrence of neurogenic erectile dysfunction, particularly n diabetes mellitus and following radical pelvic surgery. In both instances, cavernous nerve disruption is the purported cause for the erectile dysfunction. However, definitive clinical diagnoses are not possible without measure of cavernous nerve function; this will require neurophysiologic methodologies such as EGA. The studies proposed in this application will be the first steps in validating a diagnostic test of cavernous nerve unction. The ability to detect cavernous neuropathy is relevant to the evaluation of erectile dysfunction, as well as the development of disease-specific treatments for neurogenic erectile dysfunction.

描述（由申请人提供）： .阴茎自主神经支配的评估 海绵体神经提供阴茎的自主神经支配，对于健康的勃起功能至关重要。然而，目前尚未通过任何广泛接受的方法测试人类海绵体神经病。该提案的主要目的是使用电生理技术研究海绵体神经功能。我们的假设是，海绵体内诱发的电活动，称为诱发海绵体活动，是海绵体神经阴茎神经支配完整性的衡量标准。本提案的具体目标是： 1. 测量健康、强壮男性交感神经系统激活后诱发的海绵体活动，以及 2. 测量因勃起功能障碍而患有勃起功能障碍的男性交感神经系统激活后诱发的海绵体活动。海绵体神经损伤。海绵体神经的完整性将通过使用经修改用于男性生殖器的标准临床电生理设备记录海绵体中表现的电活动来确定。由交感神经纤维的激活刺激的电脉冲的存在将表明海绵体神经的身体神经支配的完整性。我们将用电生理数据证实勃起功能的测量结果。这些研究是由于神经源性勃起功能障碍的显着发生而引起的，特别是糖尿病和根治性盆腔手术后。在这两种情况下，海绵体神经破坏被认为是勃起功能障碍的原因。然而，如果不测量海绵神经功能，就不可能做出明确的临床诊断。这将需要 EGA 等神经生理学方法。本申请中提出的研究将是验证海绵神经功能诊断测试的第一步。检测海绵状神经病的能力与勃起功能障碍的评估以及针对神经源性勃起功能障碍的疾病特异性治疗的开发相关。