4-D IMRT: Imaging, Planning and Delivery

4-D IMRT：成像、计划和交付

• 批准号: 7070600
• 负责人: PAUL J KEALL
• 金额: $ 25.84万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7070600
• 关键词: bioimaging /biomedical imaging; clinical research; computed axial tomography; human subject; human therapy evaluation; lung imaging /visualization /scanning; lung neoplasms; medical complication; patient oriented research; pneumonia; radiation therapy; radiation therapy dosage; technology /technique development

DESCRIPTION (provided by applicant): Studies performed over the past decade give evidence that for lung cancer, increased radiotherapy dose will lead to better local control and survival. Further studies show that the main lung cancer radiotherapy side effect, pneumonitis, can be significantly reduced by lowering the dose delivered to healthy lung tissue. Balancing these conflicting goals is difficult, especially since a lung tumor moves on average 1.5-2 cm with respiratory motion. This project aims to develop and implement a technique entitled 4D IMRT (4-Dimensional Intensity Modulated Radiation Therapy). The 4th dimension, or time, component of the technique means that the tumor motion is accounted for during the imaging, planning and delivery of radiation. Tracking the tumor with the radiation beam during treatment delivery allows a reduction in beam margin and consequently a reduction in the volume of healthy tissue exposed to a high dose. The IMRT component of the technique allows us to give a sufficiently high dose to the tumor and an acceptably low dose to the healthy lung tissue. We will investigate the hypotheses that 4D IMRT will lead to: 1. improved treatment plans compared with conventional IMRT, 2. reduced volumes of normal tissue exposed to injurious doses compared with conventional IMRT, 3. reduced delivery time compared with respiration-gated IMRT, 4. wider applicability than breath-hold techniques, and 5. higher accuracy in delivered dose distributions compared with conventional and respiration-gated techniques.Though the studies here will concentrate mainly on lung cancer, 4D IMRT is applicable to all sites affected by respiratory motion, including breast and liver cancer, and even cervix and prostate cancer.

描述（由申请人提供）：过去十年进行的研究证明，对于肺癌，增加放射治疗剂量将导致更好的局部控制和生存。进一步的研究表明，通过降低输送到健康肺组织的剂量，可以显着减少肺癌放疗的主要副作用——肺炎。平衡这些相互冲突的目标很困难，特别是因为肺部肿瘤随着呼吸运动平均移动 1.5-2 厘米。该项目旨在开发和实施名为 4D IMRT（4 维强度调制放射治疗）的技术。该技术的第四维或时间组成部分意味着在成像、计划和放射治疗过程中考虑了肿瘤运动。在治疗过程中用放射束跟踪肿瘤可以减少射束裕度，从而减少暴露于高剂量的健康组织的体积。该技术的 IMRT 部分使我们能够对肿瘤给予足够高的剂量，并对健康肺组织给予可接受的低剂量。我们将研究 4D IMRT 将导致的假设： 1. 与传统 IMRT 相比，改进了治疗计划； 2. 与传统 IMRT 相比，减少了暴露于有害剂量的正常组织的体积； 3. 与呼吸门控 IMRT 相比，缩短了递送时间； 4. 比屏气技术具有更广泛的适用性，以及 5. 与传统技术和呼吸门控技术相比，输送剂量分布的准确性更高。虽然这里的研究主要集中在肺癌，但 4D IMRT适用于所有受呼吸运动影响的部位，包括乳腺癌和肝癌，甚至宫颈癌和前列腺癌。