4-D IMRT: Imaging, Planning and Delivery

4-D IMRT：成像、计划和交付

• 批准号: 6892114
• 负责人: PAUL J KEALL
• 金额: $ 28.47万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2006-04-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6892114
• 关键词: bioimaging /biomedical imaging; clinical research; computed axial tomography; human subject; human therapy evaluation; lung imaging /visualization /scanning; lung neoplasms; medical complication; patient oriented research; pneumonia; radiation therapy; radiation therapy dosage; technology /technique development

DESCRIPTION (provided by applicant): Studies performed over the past decade give evidence that for lung cancer, increased radiotherapy dose will lead to better local control and survival. Further studies show that the main lung cancer radiotherapy side effect, pneumonitis, can be significantly reduced by lowering the dose delivered to healthy lung tissue. Balancing these conflicting goals is difficult, especially since a lung tumor moves on average 1.5-2 cm with respiratory motion. This project aims to develop and implement a technique entitled 4D IMRT (4-Dimensional Intensity Modulated Radiation Therapy). The 4th dimension, or time, component of the technique means that the tumor motion is accounted for during the imaging, planning and delivery of radiation. Tracking the tumor with the radiation beam during treatment delivery allows a reduction in beam margin and consequently a reduction in the volume of healthy tissue exposed to a high dose. The IMRT component of the technique allows us to give a sufficiently high dose to the tumor and an acceptably low dose to the healthy lung tissue. We will investigate the hypotheses that 4D IMRT will lead to: 1. improved treatment plans compared with conventional IMRT, 2. reduced volumes of normal tissue exposed to injurious doses compared with conventional IMRT, 3. reduced delivery time compared with respiration-gated IMRT, 4. wider applicability than breath-hold techniques, and 5. higher accuracy in delivered dose distributions compared with conventional and respiration-gated techniques.Though the studies here will concentrate mainly on lung cancer, 4D IMRT is applicable to all sites affected by respiratory motion, including breast and liver cancer, and even cervix and prostate cancer.

描述（由申请人提供）：在过去的十年中进行的研究表明，对于肺癌，放射治疗剂量增加将导致更好的局部控制和生存。进一步的研究表明，通过降低递送到健康的肺组织的剂量，可以显着降低主要的肺癌放疗副作用，肺炎。平衡这些相互矛盾的目标是困难的，尤其是因为肺部肿瘤平均以呼吸运动为1​​.5-2厘米。该项目旨在开发和实施标题为4D IMRT的技术（4维强度调节辐射疗法）。该技术的第四维或时间成分意味着在辐射的成像，计划和传递过程中，肿瘤运动是考虑到肿瘤运动的。在处理过程中，用辐射束跟踪肿瘤可以减少光束边缘，从而减少暴露于高剂量的健康组织的体积。该技术的IMRT成分使我们能够为肿瘤提供足够高的剂量，并对健康的肺组织提供低剂量。我们将调查以下假设：与常规IMRT相比，4D IMRT将导致：1。改进的治疗计划，2。与常规IMRT相比，暴露于有害剂量的正常组织的体积减少，与呼吸器的IMRT相比，与呼吸技术相比，与呼吸技术的分配相比，与传统的IMRT相比，交付时间减少了3。技术。尽管这里的研究将主要集中于肺癌，但4D IMRT适用于所有受呼吸运动影响的部位，包括乳腺癌和肝癌，甚至包括子宫颈和前列腺癌。