Prevention &Treatment of HIV/AIDS in Adults and Children

预防

• 批准号: 6730133
• 负责人: ALEXANDER S CHERNOV
• 金额: $ 5.39万
• 依托单位: TOMSK REG CTR/PREVENTION & TREATMENT
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6730133
• 关键词: AIDS education /prevention; AIDS therapy; Commonwealth of Independent States; HIV infections; Mycobacterium tuberculosis; comorbidity; ethics; microorganism disease chemotherapy; placental transfer; prenatal care; statistics /biometry; training; vertical transmission

DESCRIPTION (provided by applicant): Specific Aims. The goal of this proposal is to enable the Tomsk Regional Center for AIDS and other Infectious Diseases (TRCAID) to (1) plan and develop a comprehensive HIV/AIDS prevention and treatment research agenda relevant to its patient population and (2) enhance the infrastructure necessary for the Center to conduct such research. The result will be to develop a CIPRA U01 grant application in approximately two years. R03 funding will allow the TRCAID to develop additional institutional infrastructure and provide appropriate training as well as begin the process of data collection and research design necessary to achieve that goal. Background and Significance. The AIDS epidemic is spreading faster in the former Soviet bloc than anywhere else in the world. The Tomsk Oblast, in southwestern Siberia, where the epidemiological impact of HIV, TB, and STDs is much worse than for the European part of Russia. TRCAID is the best-equipped facility in the region to address the NIAID CIPRA priorities and develop independent research capability. Research Design and Methods. This planning grant will use three strategies: (1) creation of an External Advisory Committee composed of (a) faculty at Baylor College of Medicine in Houston, Texas, and local and regional healthcare leaders in Tomsk. The Baylor faculty will mentor the TRCAID personnel who will develop a functioning research infrastructure over the next two years. The Russian advisors will provide links to the local and federal ministries of health so that TRCAID can effectively implement the training and suggestions provided by the address the tasks necessary to build a research infrastructure at TRCAID; and (3) a process of learning by doing, by which TRCAID staff will be mentored as they develop plans for the CIPRA U01 application that will be submitted in two years. The project will provide professional development related to (1) prevention and treatment of HIV/AIDS according to current WHO and western standards; (2) medical ethics, protection of human subjects, and establishment of an institutional review board (IRB) for protection of human subjects; (3) biostatistics and research design; and (4) English language training for designated TRCAID staff and investigators directly involved in the current R03 and anticipated U01 projects. TRCAID staff will design a research project related to prevention of mother-to-child-transmission (MTCT), including assessment of HIV and barriers to prenatal care in Tomsk Region and development of targeted patient education materials. TRCAID will also identify appropriate and optimal HIV/AIDS drug regimens and ascertain their availability, especially in the context of HIV-associated co-morbid infections such as mycobacterium tuberculosis. Over the two years of the grant, there will be approximately 15 exchange visits between Tomsk and Houston.

描述（由申请人提供）：具体目标。该提案的目标是使托木斯克地区艾滋病和其他传染病中心 (TRCAID) 能够 (1) 规划和制定与其患者群体相关的全面的艾滋病毒/艾滋病预防和治疗研究议程，以及 (2) 加强基础设施中心开展此类研究是必要的。结果将是在大约两年内完成 CIPRA U01 拨款申请。 R03 资金将使 TRCAID 能够开发额外的机构基础设施并提供适当的培训，并开始实现该目标所需的数据收集和研究设计过程。背景和意义。艾滋病疫情在前苏联集团的传播速度比世界其他任何地方都快。位于西伯利亚西南部的托木斯克州，艾滋病毒、结核病和性病的流行病学影响比俄罗斯欧洲部分严重得多。 TRCAID 是该地区设备最齐全的机构，可解决 NIAID CIPRA 优先事项并发展独立研究能力。研究设计和方法。该规划拨款将采用三种策略：(1) 建立一个外部咨询委员会，由 (a) 德克萨斯州休斯顿贝勒医学院的教员以及托木斯克当地和地区医疗保健领导者组成。贝勒大学的教员将指导 TRCAID 人员，他们将在未来两年内开发一个有效的研究基础设施。俄罗斯顾问将提供与地方和联邦卫生部的联系，以便 TRCAID 能够有效实施解决在 TRCAID 建立研究基础设施所需任务所提供的培训和建议； (3) 边做边学的过程，TRCAID 工作人员在为两年内提交的 CIPRA U01 申请制定计划时将得到指导。该项目将提供与（1）根据现行世界卫生组织和西方标准预防和治疗艾滋病毒/艾滋病相关的专业发展； （2）医学伦理、人类受试者保护以及建立保护人类受试者的机构审查委员会（IRB）； （3）生物统计学和研究设计； (4) 对直接参与当前 R03 和预期 U01 项目的指定 TRCAID 工作人员和研究人员进行英语语言培训。 TRCAID 工作人员将设计一个与预防母婴传播（MTCT）相关的研究项目，包括评估托木斯克地区的艾滋病毒和产前护理障碍以及开发有针对性的患者教育材料。 TRCAID 还将确定适当和最佳的艾滋病毒/艾滋病药物治疗方案并确定其可用性，特别是在与艾滋病毒相关的共病感染（例如结核分枝杆菌）的情况下。在资助的两年内，托木斯克和休斯顿之间将进行大约 15 次互访。