Socioeconomic Status, Stress & Asthma Biological Markers

社会经济地位、压力

• 批准号: 7121808
• 负责人: EDITH CHEN
• 金额: $ 26.37万
• 依托单位: UNIVERSITY OF BRITISH COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7121808
• 关键词: adolescence (12-20); asthma; behavioral /social science research tag; biomarker; clinical research; cortisol; cytokine; disease /disorder proneness /risk; gene environment interaction; human subject; interview; longitudinal human study; low socioeconomic status; middle childhood (6-11); outcomes research; psychological stressor; public health; respiratory disorder epidemiology; respiratory function; social support network; statistics /biometry; violence

DESCRIPTION (provided by applicant): Low socioeconomic status (SES) has a profound influence on physical health outcomes throughout the lifespan. For example, the most common childhood chronic health condition, asthma, is more severe in low SES children. Understanding the reasons why low SES children suffer from worse asthma thus has important public health implications. This proposed project seeks a more thorough understanding of both psychological and biological pathways that could help to explain epidemiological findings linking low SES with increased asthma severity. The focus will be on the effects of SES on stress and biological systems that have been implicated in asthma exacerbations. The specific aims of this proposal include: 1) Examining the dimensions of SES (prestige SES, resource SES, relative SES) that are associated with asthma biological processes, and considering the implications of these associations for our understanding of how SES impacts asthma; 2) Determining which components of stress (stress exposure, stress interpretations, stress reactivity) form psychological pathways between SES and asthma biological processes; and 3) Identifying psychological factors that characterize a subgroup of vulnerable children (low SES) who are resilient (have good asthma profiles). This last aim will entail assessing child characteristics (e.g., control) as well as social network factors as potential buffers of the SES and asthma relationship. We will recruit a sample of 120 children (ages 13-18) with persistent asthma. Children will be interviewed about life stresses and parents interviewed about family SES. Biological processes implicated in asthma, including immune markers (e.g., cytokines) and neuroendocrine hormones (salivary cortisol), as well as asthma outcomes (e.g., pulmonary function) will be assessed. Children will be tested 5 times over a 2-year period to track changes in stress and asthma. The results from this project will allow us to begin developing models of how the larger social environment comes to affect a child's clinical course of asthma.

描述（由申请人提供）：低社会经济地位（SES）对整个生命周期的身体健康结果有着深远的影响。例如，最常见的儿童慢性疾病——哮喘，在社会经济地位低的儿童中更为严重。因此，了解低社会经济地位儿童患有更严重哮喘的原因对于公共卫生具有重要意义。该拟议项目旨在更全面地了解心理和生物学途径，这有助于解释低社会经济地位与哮喘严重程度增加之间的流行病学发现。重点是 SES 对与哮喘恶化有关的压力和生物系统的影响。该提案的具体目标包括： 1) 检查与哮喘生物过程相关的 SES 维度（声望 SES、资源 SES、相对 SES），并考虑这些关联对我们理解 SES 如何影响哮喘的影响； 2）确定压力的哪些组成部分（压力暴露、压力解释、压力反应）形成SES和哮喘生物过程之间的心理通路； 3) 确定具有复原力（具有良好哮喘特征）的弱势儿童亚群（低社会经济地位）的心理因素。最后一个目标将需要评估儿童特征（例如控制）以及社交网络因素作为社会经济地位和哮喘关系的潜在缓冲因素。我们将招募 120 名患有持续性哮喘的儿童（13-18 岁）作为样本。儿童将接受有关生活压力的采访，家长也将接受有关家庭社会经济地位的采访。将评估与哮喘有关的生物过程，包括免疫标记物（例如细胞因子）和神经内分泌激素（唾液皮质醇）以及哮喘结果（例如肺功能）。儿童将在两年内接受 5 次测试，以追踪压力和哮喘的变化。该项目的结果将使我们能够开始开发更大的社会环境如何影响儿童哮喘临床病程的模型。