Socioeconomic Status, Stress & Asthma Biological Markers

社会经济地位、压力

• 批准号: 7477093
• 负责人: EDITH CHEN
• 金额: $ 25.6万
• 依托单位: UNIVERSITY OF BRITISH COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-15 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7477093
• 关键词: Acute; Affect; Age; Asthma; Belief; Biological; Biological Markers; Biological Process; Bronchodilator Agents; Buffers; Caring; Characteristics; Child; Childhood; Chronic; Chronic stress; Clinical; Communities; Condition; Dimensions; Education; Event; Exhibits; Exposure to; Family; Family Relationship; Forced expiratory volume function; Goals; Health; Hormones; Hydrocortisone; Immunologic Markers; Income; Interview; Irritants; Laboratories; Life; Life Stress; Life Style; Link; Longevity; Measures; Medical; Modeling; Neurosecretory Systems; Numbers; Occupations; Outcome; Parents; Pathway interactions; Principal Investigator; Production; Psychological Factors; Public Health; Recruitment Activity; Relative (related person); Reporting; Research; Resources; Salivary; Sampling; Savings; Self Efficacy; Severities; Social Environment; Social Network; Social status; Social support; Socioeconomic Status; Stress; Subgroup; Symptoms; System; Testing; Thinking; Time; Visit; cytokine; environmental allergen; gene environment interaction; low socioeconomic status; member; optimism; programs; psychologic; pulmonary function; resilience; response; social; stressor

DESCRIPTION (provided by applicant): Low socioeconomic status (SES) has a profound influence on physical health outcomes throughout the lifespan. For example, the most common childhood chronic health condition, asthma, is more severe in low SES children. Understanding the reasons why low SES children suffer from worse asthma thus has important public health implications. This proposed project seeks a more thorough understanding of both psychological and biological pathways that could help to explain epidemiological findings linking low SES with increased asthma severity. The focus will be on the effects of SES on stress and biological systems that have been implicated in asthma exacerbations. The specific aims of this proposal include: 1) Examining the dimensions of SES (prestige SES, resource SES, relative SES) that are associated with asthma biological processes, and considering the implications of these associations for our understanding of how SES impacts asthma; 2) Determining which components of stress (stress exposure, stress interpretations, stress reactivity) form psychological pathways between SES and asthma biological processes; and 3) Identifying psychological factors that characterize a subgroup of vulnerable children (low SES) who are resilient (have good asthma profiles). This last aim will entail assessing child characteristics (e.g., control) as well as social network factors as potential buffers of the SES and asthma relationship. We will recruit a sample of 120 children (ages 13-18) with persistent asthma. Children will be interviewed about life stresses and parents interviewed about family SES. Biological processes implicated in asthma, including immune markers (e.g., cytokines) and neuroendocrine hormones (salivary cortisol), as well as asthma outcomes (e.g., pulmonary function) will be assessed. Children will be tested 5 times over a 2-year period to track changes in stress and asthma. The results from this project will allow us to begin developing models of how the larger social environment comes to affect a child's clinical course of asthma.

描述（由申请人提供）：低社会经济地位（SES）对整个生命周期的身体健康成果产生了深远的影响。例如，在低SES儿童中，最常见的儿童慢性健康状况更为严重。理解低SES儿童因此哮喘的原因具有重要的公共卫生影响。该拟议的项目寻求对心理和生物学途径的更彻底的了解，这可以帮助解释将低SES与哮喘严重程度增加的流行病学发现联系起来。重点将放在SES对与哮喘加重有关的压力和生物系统的影响。该提案的具体目的包括：1）检查与哮喘生物学过程相关的SES（声望SES，资源SES，相对SES）的维度，并考虑这些关联对我们对SES如何影响哮喘的理解的含义； 2）确定压力的组成部分（压力暴露，压力解释，压力反应性）在SES和哮喘生物学过程之间形成心理途径； 3）识别表征具有弹性的脆弱儿童（低SES）亚组（具有良好哮喘特征）的心理因素。最后一个目标将需要评估儿童特征（例如控制）以及社交网络因素，作为SES和哮喘关系的潜在缓冲。我们将招募有120名儿童（13-18岁）和持续性哮喘的样本。关于生活压力的孩子将接受采访，父母接受了有关家庭SES的采访。将评估与哮喘有关的生物学过程，包括免疫标记（例如细胞因子）和神经内分泌激素（唾液皮质醇）以及哮喘结果（例如肺功能）。在2年的时间内，将对儿童进行5次测试，以跟踪压力和哮喘的变化。该项目的结果将使我们能够开始开发模型，了解更大的社会环境如何影响儿童的哮喘临床过程。