ADH and ALDH2 Genes in Tanzanian Populations

坦桑尼亚人群中的 ADH 和 ALDH2 基因

• 批准号: 7013185
• 负责人: Kenneth K. KIDD
• 金额: $ 3.12万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-01-15 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7013185
• 关键词: Africa; alcoholism /alcohol abuse; aldehyde dehydrogenases; alleles; clinical research; ethanol; genetic polymorphism; health science research support; human subject; international cooperation; metabolism; patient oriented research; population genetics; statistics /biometry

DESCRIPTION (provided by applicant): This is a revised application for a project which will be done primarily in Tanzania by Dr. Sylvester L.B. Kajuna, of the Department of Biochemistry and Molecular Biology, The Hubert Kairuki Memorial University Faculty of Medicine, Dar es Salaam, Tanzania. It is an extension of an existing collaboration related to NIH grant R01AA09379-09, 5/1/03-4/30/08 but also relates to P01GM57672-06 (3/1/04-2/28/09). The overall project involves studying the genetic variation in the primary ethanol metabolizing genes and the relationships of those variants to susceptibility to alcoholism. Previous studies on this project have shown that one functional variant of the ADH1B gene (ADH1B*369Cys, previously named ADH2*3)is African-specific and occurs in several African populations, including the Chagga studied in collaboration with Dr. Kajuna. This proposal is designed to provide Dr. Kajuna with operation supplies so that his laboratory in Dar es Salaam can be more directly involved in the molecular work and can study additional populations in Tanzania for this known functional variant and can look for addition! variants that might exist in the highly diverse populations of Tanzania. In addition, with local facilities and supplies it will be possible to test directly whether the ADH1B*369Cys allele is associated with a protective effect against alcoholism. As in most countries, alcoholism is a significant public health problem in Tanzania. The research will be coordinated with the ongoing studies at Yale (under AA09379) with training and protocol development taking place at Yale for laboratory studies to be undertaken in Dr. Kajuna's laboratory at The Hubert Kairuki Memorial Univeristy. An additional benefit of a functioning laboratory at HKMU is that it will allow laboratory training for student and junior researchers in molecular methodology that is not otherwise present.

描述（由申请人提供）：这是一个修订的项目申请，该项目将主要由Sylvester L.B.博士在坦桑尼亚进行。坦桑尼亚达累斯萨拉姆的Hubert Kairuki纪念大学医学院生物化学和分子生物学系Kajuna。它是与NIH授予R01AA09379-09、5/1/03-4/30/08有关的现有协作的扩展，但也与P01GM57672-06（3/1/1/04-2/28/09）有关。整个项目涉及研究原发性乙醇代谢基因的遗传变异以及这些变体对酒精中毒易感性的关系。对该项目的先前研究表明，ADH1B基因的一个功能变体（ADH1B*369CYS，以前称为ADH2*3）是非洲特异性的，并且发生在几个非洲人群中，包括与Kajuna博士合作学习的Chagga。该提案旨在为Kajuna博士提供操作供应，以便他在达累斯萨拉姆的实验室可以更直接地参与分子工作，并可以研究坦桑尼亚的其他人群，以供这种已知的功能变体，并可以增加添加！在坦桑尼亚高度多样化的种群中可能存在的变体。此外，借助当地的设施和供应，可以直接测试ADH1B*369 -CYS等位基因是否与抗酒精中毒的保护作用有关。与大多数国家一样，酒精中毒在坦桑尼亚是一个重大的公共卫生问题。这项研究将与在耶鲁大学（根据AA09379下）正在进行的研究进行协调，并在耶鲁大学进行培训和协议开发，以在Hubert Kairuki Memorial Univerristy的Kajuna博士实验室进行实验室研究。在HKMU的运行实验室的另一个好处是，它将允许为学生和初级研究人员进行分子方法学的实验室培训，而这些研究人员否则就不存在。