FMRI OF VISUALLY MEDIATED EXPLICIT MEMORY IN AGING & AD

衰老过程中视觉介导的外显记忆的 FMRI

• 批准号: 6735669
• 负责人: JULIANNA BATES
• 金额: $ 12.46万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6735669
• 关键词: Alzheimer' s disease; age difference; aging; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; cognition; functional magnetic resonance imaging; human old age (65+); human subject; memory; neural information processing; neurobiology; visual perception; young adult human (21-34)

DESCRIPTION (Adapted from the application): This is an application for a Mentored Research Scientist Development Award (MRSDA) entitled "fMRI of Visually Mediated Explicit Memory in Aging and AD". The overarching goal of this application is to utilize whole brain functional imaging techniques to study structure-function relationships subserving explicit memory in normal aging and Alzheimer's disease (AD). Functional MRI provides a unique opportunity to investigate the distributed anatomical systems engaged in this form of memory processing, which is known to be affected in normal aging, and is generally the earliest cognitive change detected in AD. An integrated series of studies is planned with the following goals: (1) to assess the relative contributions of visual perception and visual encoding to both memory performance and patterns of brain activation detected with fMRI in healthy young and elderly subjects and patients with mild AD, by studying visuospatial and visuofeature perception in both groups, (2) to study encoding of visuospatial and visuofeature stimuli with fMRI, and (3) to study effects of cognitive strategy on both visouspatial and visuofeature encoding processes in young, elderly and AD subjects. It is hypothesized that any beneficial effects of strategy will be reflected not only by chnages in memory performance but also by systematic changes in brain activation patterns. In addition, the candidate proposes to seek training in: (1) the basic neurobiology of memory, (2) cognitive psychology and neuropsychology, particularly as it pertains to aging and AD, (3) fMRI physics and analytic techniques, and (4) statistical approaches to both functional imaging and cognitive studies.

描述（改编自应用程序）： 这是指导研究科学家发展奖的申请 (MRSDA) 题为“衰老和 AD 中视觉介导的外显记忆的功能磁共振成像”。 该应用程序的总体目标是利用全脑功能 研究结构-功能关系的成像技术 正常衰老和阿尔茨海默病（AD）中的外显记忆。功能性核磁共振 提供了一个独特的机会来研究分布式解剖学 从事这种形式的内存处理的系统，众所周知 正常衰老过程中会受到影响，通常是最早的认知变化 在 AD 中检测到。 计划进行一系列综合研究，目标如下：(1) 评估视觉感知和视觉编码的相对贡献 功能磁共振成像检测到的记忆表现和大脑激活模式 健康的年轻和老年受试者以及患有轻度 AD 的患者，通过研究 两组的视觉空间和视觉特征感知，（2）研究编码 使用功能磁共振成像 (fMRI) 分析视觉空间和视觉特征刺激，以及 (3) 研究效果 视觉空间和视觉特征编码过程的认知策略 在年轻人、老年人和 AD 受试者中。据推测，任何有益的 策略的效果不仅会反映在记忆的变化上 表现还取决于大脑激活模式的系统变化。 此外，候选人建议寻求以下方面的培训：（1）基本知识 记忆神经生物学，（2）认知心理学和神经心理学， 特别是与衰老和 AD 相关的问题，(3) 功能磁共振成像物理和分析 技术，以及（4）功能成像和 认知研究。