FMRI OF VISUALLY MEDIATED EXPLICIT MEMORY IN AGING & AD

衰老过程中视觉介导的外显记忆的 FMRI

• 批准号: 6128371
• 负责人: JULIANNA BATES
• 金额: $ 10.4万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-05-01 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6128371
• 关键词: Alzheimer's disease; age difference; aging; bioimaging /biomedical imaging; brain imaging /visualization /scanning; clinical research; cognition; functional magnetic resonance imaging; human old age (65+); human subject; memory; neural information processing; neurobiology; visual perception; young adult human (21-34)

DESCRIPTION (Adapted from the application): This is an application for a Mentored Research Scientist Development Award (MRSDA) entitled "fMRI of Visually Mediated Explicit Memory in Aging and AD". The overarching goal of this application is to utilize whole brain functional imaging techniques to study structure-function relationships subserving explicit memory in normal aging and Alzheimer's disease (AD). Functional MRI provides a unique opportunity to investigate the distributed anatomical systems engaged in this form of memory processing, which is known to be affected in normal aging, and is generally the earliest cognitive change detected in AD. An integrated series of studies is planned with the following goals: (1) to assess the relative contributions of visual perception and visual encoding to both memory performance and patterns of brain activation detected with fMRI in healthy young and elderly subjects and patients with mild AD, by studying visuospatial and visuofeature perception in both groups, (2) to study encoding of visuospatial and visuofeature stimuli with fMRI, and (3) to study effects of cognitive strategy on both visouspatial and visuofeature encoding processes in young, elderly and AD subjects. It is hypothesized that any beneficial effects of strategy will be reflected not only by chnages in memory performance but also by systematic changes in brain activation patterns. In addition, the candidate proposes to seek training in: (1) the basic neurobiology of memory, (2) cognitive psychology and neuropsychology, particularly as it pertains to aging and AD, (3) fMRI physics and analytic techniques, and (4) statistical approaches to both functional imaging and cognitive studies.

描述（根据应用程序改编）： 这是指导研究科学家发展奖的申请 （MRSDA）标题为“衰老和AD中视觉介导的明确记忆的fMRI”。 该应用程序的总体目标是利用整个大脑功能 研究结构功能关系的成像技术suspect 正常衰老和阿尔茨海默氏病（AD）的明确记忆。功能性MRI 提供了一个独特的机会来研究分布式解剖学 采用这种记忆处理形式的系统，已知是 在正常衰老中受到影响，通常是最早的认知变化 在AD中检测到。 计划以下目标进行一系列集成的研究：（1）到 评估视觉感知和视觉编码的相对贡献 记忆性能和用fMRI检测到的大脑激活的模式 通过研究 两组的视觉空间和视觉效果感知，（2）研究编码 通过fMRI和（3）研究效果的视觉空间和视觉刺激 在视觉过程和视觉编码过程中的认知策略 在年轻，老年人和广告主题中。假设任何有益的 策略的影响不仅将被记忆中的金钱反映 性能，还通过系统的大脑激活模式变化。 此外，候选人建议寻求培训：（1）基本 记忆神经生物学，（2）认知心理学和神经心理学， 特别是与衰老和AD有关，（3）fMRI物理学和分析 技术，以及（4）功能成像和统计方法 认知研究。