IMPROVING ANIMAL RESOURCES FOR CANCER RESEARCH AT RPCI

改善 RPCI 癌症研究的动物资源

• 批准号: 6769193
• 负责人: YOUCEF M RUSTUM
• 金额: $ 65.52万
• 依托单位: ROSWELL PARK CANCER INSTITUTE CORP
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6769193
• 关键词: air filtration; animal care; animal colony; biomedical facility; building /facility design /renovation; monitoring device

DESCRIPTION (provided by applicant): The Department of Laboratory Animal Resources (DLAR) is responsible for laboratory animal care and use by investigators at Roswell Park Cancer Institute (RPCI). In June 2002, DLAR was granted full accreditation by the Association for the Assessment and Accreditation of Laboratory Animal Care International (AAALAC International). DLAR provides specialized animal husbandry; veterinary medical care; animal health surveillance; diagnostic laboratory facilities; research technical services and resources including genetically defined mice; a surgical program and technician; and faculty training in support of more than 150 Institute Animal Care and Use Committee-approved animal use protocols. DLAR is experiencing significant constraints on space for holding mice, given the aggressive recruitment that has occurred at RPCI since 2000 and the increasing emphasis on genetic approaches to the study of cancer as a result of new technologies such as transgenics. This application requests $700,000 to 1) renovate superfluous laboratory space within the existing footprint of DLAR to accommodate the developing Experimental Mouse Tumor Models Facility and holding areas for mice undergoing sequential imaging in the adjacent Preclinical MR Imaging Facility; 2) purchase of microisolater caging on ventilated racks (MIC) with automatic watering (AW) for rodents; 3) cleaning equipment; 4) an upgraded computerized environmental monitoring system, and 5) biological safety cabinets. The number of rodents in DLAR has increased 47% in the last year from 19,400 in January 2002 to 28,542 in January 2003. This trend is expected to continue. The immediate and urgent need to increase the density of rodent holding with the DLAR footprint can be addressed by the proposed renovations and the installation of MIC in the renovated area. Each MIC replacement will increase miceholding by 100 (80 x 100 = 8,000 additional mice). Automatic watering has proven to be a reliable and efficient technology which provides water on demand with cost savings in labor. An upgrade of the computerized environmental monitoring system will allow printouts to be available for multiple data points for the vivarium area in the Medical Research Complex and the proposed renovations in the vivarium area in the Cancer Cell Center. The requested Biological Safety Cabinets will ensure high husbandry standards in the renovated area.

描述（由申请人提供）： 实验室动物资源部（DLAR）负责罗斯威尔公园癌症研究所（RPCI）的研究人员使用实验室动物护理。 2002年6月，DLAR获得了实验室动物护理国际（AAAALAC International）评估和认证协会的全面认证。 DLAR提供专门的畜牧业；兽医医疗；动物健康监测；诊断实验室设施；研究技术服务和资源，包括基因定义的小鼠；外科计划和技术人员；以及教师培训，以支持150多个研究所动物护理和使用委员会批准的动物使用方案。鉴于自2000年以来一直在RPCI发生的积极募集以及由于新技术（例如转基因技术）的结果，DLAR正在对持有小鼠的空间施加重大限制。该应用要求$ 700,000至1）在现有的DLAR占地面内翻新多余的实验室空间，以适应发展中的实验性小鼠肿瘤模型设施和固定区域的小鼠在相邻的临床前MR成像设施中进行顺序成像； 2）购买带有啮齿动物的自动浇水（AW）的通风架（MIC）上的微质量式笼子； 3）清洁设备； 4）升级的计算机环境监测系统和5）生物安全柜。去年，DLAR的啮齿动物数量从2002年1月的19,400人增加到2003年1月的28,542。可以通过拟议的翻新工程和在翻新的区域安装麦克风来解决与DLAR足迹增加啮齿动物保持密度的直接需求。每个麦克风更换将使持有小鼠增加100（80 x 100 =另外8,000只小鼠）。事实证明，自动浇水是一项可靠，有效的技术，可在劳动力中节省成本。对计算机环境监测系统的升级将允许医学研究综合体中的Vivarium区域的多个数据点以及癌细胞中心的Vivarium区域的拟议翻新。所需的生物安全柜将确保在经过翻新的地区确保高级饲养标准。