Drug Development and Biocultural Diversity Conservation

药物开发和生物文化多样性保护

• 批准号: 6806433
• 负责人: PAUL ALAN COX
• 金额: $ 17.5万
• 依托单位: NATIONAL TROPICAL BOTANICAL GARDEN
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-30 至 2005-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6806433
• 关键词: Pacific Islands; antiAIDS agent; antiinfective agents; antineoplastics; aquatic organism; cardiovascular disorder chemotherapy; clinical research; computer program /software; drug design /synthesis /production; drug discovery /isolation; field study; folk medicine; human subject; international cooperation; mass spectrometry; medicinal plants; microorganism; nervous system disorder chemotherapy; phorbols; plant ecology; plant extracts; saltwater environment; sample collection; training

DESCRIPTION (provided by applicant): Broad Lonq-Term Goals and Objectives Undertake planning and coordination activities to create a full ICBG proposal that will undertake the following specific activities: Specific Aims To perform additional pre-clinical evaluations of Prostratin (for HIV/AIDS) and to discover and develop other bioactive agents of potential utility for local and international health priorities. The source of new bioactive agents or phytomedicine products will be terrestrial plants, micro-organisms and marine organisms found in of Samoa and Tonga. To create sustainable harvest programs for the harvesting of Homo/anthus nutans and develop this general capacity for the creation of local biodiversity based sustainable development of phytomedicines. To implement a highly integrated ethnomedical field research program in Samoa and Tonga that utilizes a sophisticated union of western trained medical doctors, traditional healers and ethnobotanists. To help conserve vanishing ethnomedical knowledge in these nations. To conduct inventories and collections of vascular plants and micro-organisms in these island nations where endemism of the regions flora is very high. To train and build capacity with local scientists and emerging scientific professionals. To undertake the collection of marine organisms in Samoa and Tonga and isolate compounds. Micro-organisms will also be isolated from these materials and screened for antinfective activity. To screen plant extracts and compounds derived from terrestrial and marine environments for anti-infective, CNS, anti-cancer, cardiovascular and phytomedicine applications.

描述（由申请人提供）： 广泛的长期目标和目标 开展规划和协调活动，以创建完整的 ICBG 提案，该提案将开展以下具体活动： 具体目标 对 Prostratin（针对 HIV/艾滋病）进行额外的临床前评估并发现和开发对当地和国际卫生优先事项具有潜在用途的其他生物活性剂。新的生物活性剂或植物药产品的来源将是萨摩亚和汤加发现的陆地植物、微生物和海洋生物。制定可持续收获计划来收获人/花果，并发展这种总体能力，以创造基于当地生物多样性的植物药可持续发展。在萨摩亚和汤加实施高度综合的民族医学实地研究计划，利用受过西方培训的医生、传统治疗师和民族植物学家的复杂联合。帮助保护这些国家正在消失的民族医学知识。在这些岛国进行维管束植物和微生物的清查和收集，这些岛国的植物特有性非常高。对当地科学家和新兴科学专业人员进行培训和能力建设。负责在萨摩亚和汤加收集海洋生物并分离化合物。微生物也将从这些材料中分离出来并筛选其抗感染活性。筛选来自陆地和海洋环境的植物提取物和化合物，用于抗感染、中枢神经系统、抗癌、心血管和植物医学应用。

项目成果

Variability in content of the anti-AIDS drug candidate prostratin in Samoan populations of Homalanthus nutans.

萨摩亚 Homalanthus nutans 群体中抗艾滋病候选药物 Prostratin 含量的差异。

• 发表时间: 2008-12
• 影响因子: 5.1
• 作者: Johnson, Holly E;Banack, Sandra A;Cox, Paul Alan
• 通讯作者: Cox, Paul Alan