Molecular Analysis of Vascular Development

血管发育的分子分析

• 批准号: 7025624
• 负责人: THOMAS N SATO
• 金额: $ 41.01万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-02-01 至 2009-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7025624
• 关键词: angiogenesis; angiopoietins; developmental genetics; gene expression; gene interaction; gene targeting; genetically modified animals; growth factor receptors; laboratory mouse; protein protein interaction; protein tyrosine kinase; vascular endothelial growth factors

DESCRIPTION (provided by applicant): My long-term goal is to understand molecular mechanisms underlying mammalian vascular system development. We are primarily interested in how endothelial-specific receptor tyrosine kinases regulate vascular development. Our proposed studies aim to understand the precise roles of molecules that are involved in the regulation of vascular development. We have gained significant information regarding the roles of many molecules in vascular development in the past years. However, many important questions still need to be addressed. Furthermore, normal functional development of almost all organs depends on vascularization. Therefore, our study of vascular development also contributes to the more complete understanding of the organogenesis in general. Most importantly, the pathogenesis of many human diseases involves new blood vessel formation or regression. Thus, our studies of vascular development will contribute to the invention of unique and effective therapeutic approaches targeted towards many human diseases such as heart failure, stroke, cancer, wound healing, and diabetic retinopathy.

描述（由申请人提供）：我的长期目标是了解哺乳动物血管系统开发的分子机制。我们主要对内皮特异性受体酪氨酸激酶如何调节血管发育感兴趣。我们提出的研究旨在了解与血管发育调节有关的分子的确切作用。在过去几年中，我们获得了有关许多分子在血管发育中的作用的重要信息。但是，仍然需要解决许多重要的问题。此外，几乎所有器官的正常功能发展都取决于血管化。因此，我们对血管发育的研究也有助于对总体上对器官发生的更完整的了解。最重要的是，许多人类疾病的发病机理涉及新的血管形成或回归。因此，我们对血管发育的研究将有助于针对许多人类疾病（例如心力衰竭，中风，癌症，伤口愈合和糖尿病性视网膜病）的独特有效治疗方法的发明。