Lymphocyte Activation and Signaling

淋巴细胞激活和信号转导

• 批准号: 7058629
• 负责人: GARY A. KORETZKY
• 金额: $ 0.75万
• 依托单位: KEYSTONE SYMPOSIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058629
• 关键词: biological signal transduction; leukocyte activation /transformation; meeting /conference /symposium; travel

The cells of the immune system are armed with a dizzying array of signaling receptors requiring them to integrate an enormous amount of information about their environment to mount the appropriate biologic response. Over the last several years much has been learned about the biochemical nature of the signaling cascades initiated by interactions of individual receptors with their ligands. This progress presents an exciting new challenge, namely, to understand how multiple signals are integrated in the context of the entire cell to bring about the ultimate cellular response. We propose to bring together distinguished scientists working at the cutting edge of immune cell signaling to describe their new findings and to address how these issues relate to human disease. The proposed meeting will provide a view of how the initial encounter of immune cell signaling receptor with their ligands ultimately leads to the biological response be it activation, differentiation, movement, or cell death and how this knowledge is being translated to important clinical problems in autoimmunity, immunodeficiency, vaccines, tumor immunity, transplantation and infectious diseases. The organizers of this conference have designed a program that will bring together principal investigators, fellows and students who are exploring how signaling pathways are integrated within and among immune cells to yield the appropriate response and how these signaling pathways may be manipulated to alter immune cell function for therapeutic purposes.

免疫系统的细胞配备了一系列令人眼花缭乱的信号受体，要求它们整合大量有关环境的信息，以产生适当的生物反应。在过去的几年中，人们对单个受体与其配体相互作用引发的信号级联的生化性质有了很多了解。这一进展提出了一个令人兴奋的新挑战，即了解多个信号如何在整个细胞的背景下整合以带来最终的细胞反应。我们建议将研究免疫细胞信号传导前沿的杰出科学家聚集在一起，描述他们的新发现，并解决这些问题与人类疾病的关系。拟议的会议将提供关于如何初步接触的观点 免疫细胞信号传导受体及其配体最终导致生物反应，无论是激活、分化、运动还是细胞死亡，以及如何将这些知识转化为自身免疫、免疫缺陷、疫苗、肿瘤免疫、移植和传染病等重要的临床问题。本次会议的组织者设计了一个计划，将汇集主要研究人员、研究员和学生，他们正在探索信号通路如何在免疫细胞内部和之间整合以产生适当的反应，以及如何操纵这些信号通路来改变免疫细胞功能出于治疗目的。