Sjogren's: Transition from Autoimmunity to Lymphoma

干燥症：从自身免疫到淋巴瘤的转变

• 批准号: 6941014
• 负责人: ELAINE ALEXANDER
• 金额: $ 4.9万
• 依托单位: SJOGREN'S SYNDROME FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-23 至 2006-06-22
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941014
• 关键词: Sjogren' s syndrome; apoptosis; autoimmunity; biological signal transduction; immune response; leukocyte activation /transformation; lymphoma; meeting /conference /symposium; pathologic process; travel; workshop

DESCRIPTION (provided by applicant): "Sjogrens:Transitions from Autoimmunity to Lymphoma" is a Sjogrens Syndrome Foundation basic scientific workshop scheduled for Sept. 23-25, 2005 and is designed to foster the exchange of scientific data and catalyze rigorous discussion about potential triggers in the transition from autoimmunity to lymphoma. The workshop will generate fresh and novel concepts by bringing in speakers from a variety of related fields, including researchers in immunology, autoimmunity, and oncology - many of whom have not previously focused on Sjogren's syndrome. About 5-10% of those with Sjogren's syndrome, one of the most common autoimmune disorders, develop lymphoma, specifically non-Hodgkin's B-cell lymphoma enriched for the histopathologic type classified as MALT, or mucosa-associated lymphoma. A clinical overview of the current treatment and knowledge about the close link between Sjogren's and lymphoma will set the stage for subsequent discussions about basic scientific questions surrounding that link. Participating investigators will present their most recent discoveries in the potential role of the following burgeoning areas on the emergence and treatment of lymphoma in Sjogren's: B-cell and T-cell mechanisms; B-Lymphocyte Stimulator (BLyS); genetics; programmed cell death; signaling pathways; transcription factors of the Runt-domain family; breaks or checkpoints in the control of immune response and cell proliferation in which lymphoproliferation might transform into a malignancy; and definition of new directions, future research initiatives, areas for collaboration, and registries. To inspire young investigators to undertake basic research related to the lymphoma-autoimmune transition, each speaker will be invited to select a particularly talented investigator from their laboratory to attend and participate in workshop discussions and present posters during a special session.

描述（由申请人提供）：“ Sjogrens：从自身免疫到淋巴瘤的过渡”是一个计划于2005年9月23日至25日举行的Sjogrens综合基金会基础科学研讨会，旨在促进科学数据的交流，并促进有关从自动免疫性肿瘤肿瘤瘤的潜在触发的严格讨论。该研讨会将通过引入各种相关领域的演讲者，包括免疫学，自身免疫性和肿瘤学的研究人员来产生新鲜和新颖的概念 - 其中许多以前并未专注于Sjogren综合征。大约5-10％的患有Sjogren综合征的患者是最常见的自身免疫性疾病之一，患有淋巴瘤，特别是非霍奇金的B细胞淋巴瘤，富含被分类为麦芽的组织病理学类型或粘膜相关淋巴瘤。当前治疗方法和有关Sjogren和淋巴瘤之间紧密联系的知识的临床概述将为随后关于围绕该链接的基本科学问题的讨论奠定了基础。参与的研究人员将在以下新兴地区对Sjogren的淋巴瘤的出现和治疗：B细胞和T细胞机制的出现和治疗中的潜在作用中介绍他们的最新发现； B-淋巴细胞刺激剂（BLYS）；遗传学；程序性细胞死亡；信号通路； Runt域家族的转录因子；在控制免疫反应和细胞增殖中的断裂或检查点，其中淋巴细胞增殖可能转化为恶性肿瘤。以及新方向，未来的研究计划，协作领域和注册机构的定义。为了激发年轻的研究人员进行与淋巴瘤 - 自动免疫过渡有关的基础研究，将邀请每个发言人从实验室中选择一名特别有才华的调查员，以参加并参加研讨会讨论，并在一次特别会议期间进行海报。