FASEB Summer Conference on Phospholipases

FASEB 磷脂酶夏季会议

• 批准号: 7161886
• 负责人: Jonathan Peter Arm
• 金额: $ 1.7万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-15 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7161886
• 关键词: carboxylic ester hydrolases; meeting /conference /symposium; phosphodiesterases; phospholipase A2; phospholipase C; phospholipase D; travel

DESCRIPTION (provided by applicant): This application seeks partial funding for the eighth FASEB Summer Research Conference on Phospholipases to be held from July 8 to 13, 2006 in Saxtons River, Vermont. The funds requested will be used primarily to support the registration and travel expenses of junior investigators who will present their work at the conference as invited presentations, short talks, or posters. The overall goal of this established and successful conference is to provide a forum for review and discussion of recent research on the structure, function and integrated biology of phospholipases. These widely expressed enzymes hydrolyze ester and phosphodiester bonds in membrane phospholipids to generate bioactive lipids and lipid-derived products that regulated many and diverse aspects of cell function. Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in physiologic and pathologic processes such as renal perfusion, gastric cytoprotection, hemostasis, cancer, host defense, inflammation, and asthma. Phospholipase C generates inositol phosphate and diglyceride second messengers in response to agonist activation of cell surface receptors. Phospholipase D generates phosphatidic acid from phosphatidylcholine, to regulate organization of the actin cytoskeleton, cell growth, survival, motility and vesicular transport. The conference includes talks on the emerging areas of signaling networks and lipidomics as well as sphingolipids, which have roles in cellular stress responses, apoptosis, and cell migration. This conference brings together scientists working in diverse disciplines including biophysics, structural, cell and molecular biology, drug development, and diverse clinical disciplines that are impacted by research on phospholipases. The conference has a strong record of including contributions from international investigators and of including presentations from both junior and established investigators. It provides an effective forum for promoting collaborations and new advances in the field. The subject area receives considerable support from the NIH with approximately 400 active projects funded by each of the major NIH institutes. The field has generated approximately 2000 peer reviewed research publications in each of the last 10 years. The funds requested in this proposal will make an invaluable contribution to the support of this conference and in particular the development of young investigators.

描述（由申请人提供）： 本申请为将于 2006 年 7 月 8 日至 13 日在佛蒙特州萨克斯顿河举行的第八届 FASEB 磷脂酶夏季研究会议寻求部分资助。所申请的资金将主要用于支持初级研究人员的注册和差旅费，他们将在会议上以受邀演讲、简短演讲或海报的形式展示他们的工作。这次成功召开的会议的总体目标是为回顾和讨论磷脂酶的结构、功能和整合生物学的最新研究提供一个论坛。这些广泛表达的酶水解膜磷脂中的酯键和磷酸二酯键，产生生物活性脂质和脂质衍生产物，调节细胞功能的许多方面。磷脂酶 A 产生脂肪酸和受体活性溶血磷脂。花生四烯酸代谢为白三烯和前列腺素，它们在肾灌注、胃细胞保护、止血、癌症、宿主防御、炎症和哮喘等生理和病理过程中具有明确的作用。磷脂酶 C 响应细胞表面受体的激动剂激活而产生磷酸肌醇和甘油二酯第二信使。磷脂酶 D 从磷脂酰胆碱生成磷脂酸，调节肌动蛋白细胞骨架的组织、细胞生长、存活、运动和囊泡运输。会议包括关于信号网络和脂质组学以及鞘脂等新兴领域的讨论，鞘脂在细胞应激反应、细胞凋亡和细胞迁移中发挥作用。这次会议汇集了不同学科的科学家，包括生物物理学、结构生物学、细胞和分子生物学、药物开发以及受磷脂酶研究影响的不同临床学科。该会议拥有国际研究人员的贡献以及初级和资深研究人员的演讲的良好记录。它为促进该领域的合作和新进展提供了一个有效的论坛。该学科领域得到了 NIH 的大力支持，每个主要 NIH 研究所资助了大约 400 个活跃项目。过去 10 年，该领域每年发表约 2000 篇经过同行评审的研究出版物。本提案中要求的资金将为支持本次会议，特别是年轻研究者的发展做出宝贵贡献。