Extramural Research Facilities Improvement Program "Dru*

校外研究设施改进计划“Dru*

• 批准号: 7001006
• 负责人: Harold L. Paz
• 金额: $ 278.63万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-10-20 至 2012-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001006
• 关键词: Extramural Activities; programs; research facility

DESCRIPTION (provided by applicant): The objective of this application is to obtain matching funds to integrate and enlarge space for the existing Drug Discovery Core Facility (DDCF) of the Pennsylvania State University College of Medicine (PSUCOM). Drug discovery and development are the natural extension of basic biomedical research, and many faculty members at PSUCOM are conducting research with strong potential for the development of preventative, diagnostic or therapeutic agents. While the DDCF is an established unit and enjoys the ongoing support of PSUCOM administration, the funding requested in this application will provide the resources to: 1. Consolidate and integrate existing and planned shared resources that support drug discovery and development. 2. Meet space requirements for funded investigators, while fostering an institutional identity for the Drug Discovery Program. 3. Create expansion potential for DDCF-related infrastructure. 4. Create contiguous office space to provide dedicated data analysis workstations and to promote collaboration. 5. Create communal space for faculty and student users of the DDCF. 6. Establish laboratory and office space to enhance the training of students, postdoctoral fellows and faculty. 7. Facilitate reporting of discoveries by PSUCOM faculty and promote technology transfer. This application seeks funding to renovate a 6,600 square foot facility on the second floor of the Biomedical Research Building of the PSUCOM, in close proximity to 1,700 square feet of office and collaborative workspace, to support the Drug Discovery Program. Funding this application will have a major positive impact on the translation of basic research to clinical application within the PSUCOM.

描述（由申请人提供）： 本申请的目的是获得匹配资金，以整合和扩大宾夕法尼亚州立大学医学院（PSUCOM）现有药物发现核心设施（DDCF）的空间。药物发现和发育是基本生物医学研究的自然扩展，而Psucom的许多教职员工都在进行具有强大潜力的预防，诊断或治疗剂的潜力的研究。虽然DDCF是一个已建立的单位，并且享有Pshipom Administration的持续支持，但本申请中要求的资金将提供资源：1。巩固并整合了支持药物发现和开发的现有和计划的共享资源。 2.满足资金研究人员的空间要求，同时促进了药物发现计划的机构身份。 3。为DDCF相关的基础架构创建扩展潜力。 4.创建连续的办公空间，以提供专门的数据分析工作站并促进协作。 5。为DDCF的教师和学生用户创建公共空间。 6.建立实验室和办公空间，以增强学生的培训，博士后研究员和教师。 7。促进Phucom教师的发现并促进技术转移。该应用程序寻求资金来翻新Psucom的生物医学研究大楼二楼的6,600平方英尺的设施，紧邻1,700平方英尺的办公室和协作工作区，以支持该药物发现​​计划。资助此应用程序将对基础研究对临床应用的翻译产生重大的积极影响。

项目成果

Combined, but not individual, blockade of ASIC3, P2X, and EP4 receptors attenuates the exercise pressor reflex in rats with freely perfused hindlimb muscles.

联合而非单独阻断 ASIC3、P2X 和 EP4 受体会减弱后肢肌肉自由灌注的大鼠的运动升压反射。

• DOI: 10.1152/japplphysiol.00630.2015
• 发表时间: 2015
• 期刊: Journal of applied physiology (Bethesda, Md. : 1985)
• 作者: Stone,AudreyJ;Copp,StevenW;Kim,JoyceS;Kaufman,MarcP
• 通讯作者: Kaufman,MarcP