Mckinly Laboratory Animal Facility Renovation and Expan*

麦金利实验动物设施改造和扩建*

• 批准号: 6950472
• 负责人: CHARLES G. RIORDAN
• 金额: $ 800万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-10 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6950472
• 关键词: Accreditation; Air; Animal Model; Animals; Area; Arts; Basic Science; Cardiovascular system; Delaware; Development; Faculty; Funding; Grant; Growth; Immunocompromised Host; Institutes; International; Laboratories; Laboratory Animals; Malignant Neoplasms; Methodology; Mus; Neurosciences Research; Postdoctoral Fellow; Research; Research Personnel; Research Training; Rodent; Sanitation; System; Transgenic Mice; Transgenic Organisms; United States National Institutes of Health; Universities; animal care; animal facility; beneficiary; career development; design; facility renovation; graduate student; human disease; improved; meetings; member; mouse model; programs; research study

This proposal is to renovate and expand the laboratory animal care facility on the lower level of the McKinly Laboratory at the University of Delaware (UD), including upgrades in sanitation, air handling and support facilities. The long term objectives are to expand UD's capacity for development and utilization of transgenic mouse models of human disease in national priority areas and support the growth of cancer, cardiovascular, and neuroscience research programs. Specific aims are to (1) provide a state of the art mouse barrier unit to support the development and use of transgenic and immunocompromised animal models; (2) provide additional animal holding capacity for genetically modified rodents; (3) replace the existing 30 year old air handling system; (4) expand the sanitation area and introduce a tunnel washer to support animal facility functions; and (5) meet or exceed the facility standards for AAALAC International accreditation. The beneficiaries are UD faculty members in seven different basic science departments which are conducting cutting edge research funded by NIH institutes. The grant will make it possible to facilitate recruitment of additional NIH-funded investigators who rely on animal models; remove constraints from present NIH-funded investigators who currently must design their experiments and methodology around limited animal facilities; accelerate the career development of junior investigators; and improve research training opportunities for undergraduates, graduate students, and postdoctoral fellows.

该建议是翻新和扩大实验室动物护理设施 特拉华大学（UD）的麦金利实验室，包括卫生，空中处理和 支持设施。长期目标是扩大UD的开发和利用能力 国家优先领域中人类疾病的转基因小鼠模型，并支持 癌症，心血管和神经科学研究计划。具体目的是（1）提供 Art Mouse屏障单元支持转基因和免疫功能低下的开发和使用 动物模型； （2）为转基因啮齿动物提供额外的动物保持能力； （3） 更换现有的30年历史的空中处理系统； （4）扩大卫生区并引入 隧道洗衣机支持动物设施功能； （5）满足或超过设施标准 AAAALAC国际认证。 受益人是七个不同基础科学部门的UD教职员工 进行NIH研究所资助的尖端研究。赠款将有可能促进 招募依靠动物模型的其他NIH资助的研究人员；从中删除约束 目前由NIH资助的调查人员目前必须设计实验和方法 周围有限的动物设施；加速初级调查人员的职业发展；并改善 本科生，研究生和博士后研究员的研究培训机会。