Construction Grant 8th Floor BRB

建筑补助金 8 楼 BRB

• 批准号: 7839132
• 负责人: E. Albert Reece
• 金额: $ 500万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-01 至 2013-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7839132
• 关键词: Address; American; Area; Arts; Award; Baltimore; Cancer Center; Cancer Patient; Cellular Stress Response; Drug Design; Equipment; Extramural Activities; Floor; Funding; Goals; Grant; Hormone Responsive; Hormones; Location; Malignant Neoplasms; Maryland; Methods; Molecular; National Center for Research Resources; Occupations; Recovery; Research; Research Facilities Construction Grants; Research Personnel; Services; Silver; Structure; Time; United States Dept. of Health and Human Services; United States National Institutes of Health; Universities; anticancer research; base; design and construction; high throughput screening; interest; medical schools; multidisciplinary; novel; programs; research facility; square foot; structural biology; symposium

DESCRIPTION (provided by applicant): With the assistance of the National Center of Research Resources, National Institutes of Health, Department of Health and Human Services and funds awarded under the American Recovery Act Limited Competition: Extramural Research Facilities Improvement Program (C06), the University of Maryland Baltimore School of Medicine proposes to renovate 20,000 gross square feet of lab, office, and conference research space on the eighth floor of the Frank C. Bressler Research Building (BRB) for the Marlene and Stewart Greenebaum Cancer Center (UMGCC). At the present time, the facilities and equipment on the eighth floor of BRB are significantly outdated and unable to support cutting-edge cancer research. UMGCC investigators from the Experimental Therapeutics, Hormone Responsive Cancers, and Molecular and Structural Biology (MSB) Programs currently occupy the 9th and 10th floors of BRB. The goal of the proposed renovation is to consolidate a focused interactive group of basic investigators in the MSB Program who share overlapping research interests in the area of cellular stress responses, structural biology, and structure-based drug design. The co-location of research space will promote consolidate key collaborating investigators from the MSB Program in state-of-the art research space, thereby promoting existing and new interactions among this group and with other UMGCC investigators on the 9th and 10th floors of BRB. The proximity of these investigators will also enhance interactions with and utilization of UMGCC Shared Services, including the proposed High-Throughput Screening Lab. Thus, we envision the availability of newly renovated space will dramatically enhance UMGCC's abilities to address the unmet national need for novel and less toxic therapies for cancer patients by promoting multidisciplinary translational cancer research. The UMB SOM anticipates this project will be certified as a LEEDS silver project by incorporating sustainable methods in the design and construction of this renovation. Furthermore, approximately 120 new American jobs will be created over the course of this project and between 8 and 12 jobs will be maintained that otherwise will be eliminated. Pending approvals, and delivery of materials this project can begin as early as December 2009 and be completed by August 2011.

描述（由申请人提供）：在国家研究资源中心、国立卫生研究院、卫生与公众服务部以及根据《美国复苏法案有限竞争：校外研究设施改进计划》（C06）授予的资金的协助下，马里兰大学巴尔的摩医学院提议为 Marlene 翻新 Frank C. Bressler 研究大楼 (BRB) 八楼 20,000 总平方英尺的实验室、办公室和会议研究空间和斯图尔特格林鲍姆癌症中心 (UMGCC)。目前，BRB八楼的设施和设备明显陈旧，无法支撑前沿的癌症研究。来自实验治疗学、激素反应性癌症以及分子和结构生物学 (MSB) 项目的 UMGCC 研究人员目前占据 BRB 的 9 楼和 10 楼。拟议改造的目标是巩固 MSB 计划中一个由基础研究人员组成的重点互动小组，他们在细胞应激反应、结构生物学和基于结构的药物设计领域有着重叠的研究兴趣。 研究空间的共同定位将促进 MSB 计划的关键合作研究人员在最先进的研究空间中的整合，从而促进该小组以及与 BRB 9 层和 10 层的其他 UMGCC 研究人员之间现有和新的互动。这些研究人员的接近也将增强与 UMGCC 共享服务的互动和利用，包括拟议的高通量筛选实验室。因此，我们预计新装修的空间的可用性将极大地增强 UMGCC 的能力，通过促进多学科转化癌症研究，满足国家对癌症患者新型且毒性较小的疗法的未满足需求。 UMB SOM 预计，通过在改造的设计和施工中融入可持续方法，该项目将被认证为利兹银级项目。此外，该项目期间将在美国创造约 120 个新就业岗位，并将保留 8 至 12 个就业岗位，否则将被淘汰。该项目正在等待批准并交付材料，最早可于 2009 年 12 月开始，并于 2011 年 8 月完成。