Space Renovation for New Research Center for the Neglected Diseases of Poverty

被忽视的贫困疾病新研究中心的空间改造

• 批准号: 7877586
• 负责人: Jeffrey S Akman
• 金额: $ 1500万
• 依托单位: GEORGE WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-02-04 至 2014-07-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7877586
• 关键词: Address; Affect; African American; American; Area; Arts; Biomedical Research; Biotechnology; Certification; Chagas Disease; Commit; Complex; Cost Sharing; Diagnostic; Disadvantaged; Disease; District of Columbia; Employee; Epidemiology; Faculty; Foundations; Funding; Growth; Health Policy; Hispanic Americans; Home environment; Hookworms; Housing; Human; Individual; Infection; Journals; Life; Location; Occupations; Opisthorchiasis; Phase I Clinical Trials; Plants; Policies; Population; Poverty; Public Health; Recruitment Activity; Research; Research Personnel; Schistosomiasis; Scourge; Technology; Therapeutic; Toxocariasis; Toxoplasmosis; Translational Research; Tropical Disease; Underrepresented Minority; Universities; Vaccine Antigen; Vaccines; Vertebral column; Washington; Work; assault; cost; design; health disparity; medical schools; medical specialties; member; multidisciplinary; neglect; novel vaccines; product development; programs; research and development; research facility; square foot

DESCRIPTION (provided by applicant): The George Washington University ("GW") seeks funding to renovate approximately 25,400 net square feet of obsolete space to create a centrally located modern research complex for the new Research Center for the Neglected Diseases of Poverty in Washington, DC. The Research Center will conduct translational research for the development of new vaccines, therapeutics, and diagnostics for both neglected tropical diseases (NTDs), the devastating scourges of the "bottom billion"-the poorest people in the world who live on less than $1/day, and a unique group of neglected infections of poverty (NIPs) in the U.S. which have been recently recognized as one of the greatest health disparities affecting U.S. African American and Hispanic American populations. GW has launched a multifacted assault on these two groups of neglected diseases through its schools of medicine and public health, with faculty members conducting fundamental NIH-sponsored research on hookworm, schistosomiasis, opisthorchiasis, and toxoplasmosis, as well as epidemiological and policy work. GW is home to the Human Hookworm Vaccine Initiative (HHVI), a Gates Foundation-funded product development partnership (PDP) that is transitioning new vaccine antigens from discovery into Phase 1 trials. Also, extensive research is underway to study the major U.S. NIPs including toxocariasis, toxoplasmosis, and Chagas disease, currently affecting millions of African Americans and Hispanic Americans. A health policy initiative for both the NTDs and NIPs is also in progress at GW and we host the first open-access journal on these conditions, PLoS Neglected Tropical Diseases. While this research program at GW is strong, the physical plant that supports these investigators is so deficient it inhibits their co-location and growth of the program. This proposal aims to address these deficiencies by creating a state-of-the art research facility capable of housing the multidisciplinary researchers currently scattered across the University campus. The renovation project will employ green/sustainable technologies and design approaches, and will obtain LEED certification. All spaces will be ADA accessible. GW is fully committed to expanding the neglected diseases of poverty research program and demonstrates this through cost sharing 31% ($7.14M) of the building project costs, as well as recruiting new research-intensive tenured-track faculty in this area and creating an educational backbone for specialty biotechnology tracks and certificates for employees of the Research Center. This project will create or maintain at least 325 American jobs, with an intensive program to preferentially hire talented under-represented minority individuals from the District of Columbia and those with disadvantaged backgrounds. This project will transform and expand biomedical research at GW University, and the Research Center will significantly help address some of the greatest health disparities in the U.S. and around the world-the neglected infections of poverty and the neglected tropical diseases.

描述（由申请人提供）：乔治华盛顿大学（“GW”）寻求资金翻新约 25,400 净平方英尺的废弃空间，为华盛顿被忽视的贫困疾病新研究中心创建一个位于中心位置的现代研究综合体，直流。该研究中心将针对被忽视的热带病（NTD）开展转化研究，开发新的疫苗、治疗方法和诊断方法，这种疾病是“底层十亿人”（世界上生活费低于 1 美元的最贫困人口）的毁灭性祸害。日，以及美国独特的被忽视的贫困感染群体（NIP），这些群体最近被认为是影响美国非裔美国人和西班牙裔美国人的最大健康差异之一。乔治华盛顿大学通过其医学院和公共卫生学院对这两类被忽视的疾病发起了多方面的攻击，教职人员开展了由美国国立卫生研究院资助的关于钩虫病、血吸虫病、阿片吸虫病和弓形体病的基础研究，以及流行病学和政策工作。 GW 是人类钩虫疫苗计划 (HHVI) 的所在地，这是盖茨基金会资助的产品开发合作伙伴 (PDP)，该计划正在将新疫苗抗原从发现过渡到一期试验。此外，针对美国主要 NIP 的广泛研究正在进行中，包括弓蛔虫病、弓形体病和恰加斯病，目前影响着数百万非裔美国人和西班牙裔美国人。针对 NTD 和 NIP 的卫生政策倡议也在 GW 进行中，我们主办了第一份关于这些疾病的开放获取期刊《PLoS 被忽视的热带病》。虽然 GW 的这个研究项目很强大，但支持这些研究人员的物理设备却非常不足，以至于抑制了他们的共处一地和项目的发展。该提案旨在通过创建一个最先进的研究设施来解决这些缺陷，该设施能够容纳目前分散在大学校园内的多学科研究人员。改造项目将采用绿色/可持续技术和设计方法，并将获得LEED认证。所有空间均符合 ADA 标准。 GW 完全致力于扩大被忽视的贫困疾病研究计划，并通过分摊建筑项目成本的 31%（714 万美元）、在该领域招募新的研究密集型终身教授和创建教育研究中心员工的专业生物技术轨道和证书的骨干。该项目将创造或维持至少 325 个美国就业岗位，并实施一项强化计划，优先聘用来自哥伦比亚特区的有才华、代表性不足的少数族裔人士和具有弱势背景的人士。该项目将改变和扩大乔治城大学的生物医学研究，研究中心将极大地帮助解决美国和世界各地一些最大的健康差距——被忽视的贫困感染和被忽视的热带疾病。