NRI Build-out: Advancing Translational Brain Research

NRI 扩建：推进转化脑研究

基本信息

批准号：
7875553
负责人：
HUDA Y ZOGHBI
金额：
$ 1489.53万
依托单位：
BAYLOR COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-03-25 至 2014-03-24
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): The objective of this proposal is to build out 3 floors (total) in the Jan and Dan Duncan Neurological Research Institute (NRI) to accelerate research in understanding and treating disorders of the brain and mind. Baylor College of Medicine (BCM) and Texas Children's Hospital (TCH) investigators, through the support of six NIH institutes, HHMI, and several disease foundations, have been at the forefront of unraveling the molecular genetics of numerous neurological and neurodevelopmental disorders. The availability of excellent animal models for these disorders and the potential reversibility of several (demonstrated in mice) makes them ideally suited for an intense multidisciplinary effort to develop therapy. BCM and TCH conceived the NRI, a 350,000 sf silver-level LEED-certified research institute connecting BCM, TCH and MD Anderson, to be the first institute in the world devoted to childhood neurological disease. NRI will foster translational research in this class of diseases by 1) locating current BCM/TCH researchers working on these diseases under one roof, near TCH clinicians, 2) providing space to recruit needed expertise, and 3) establishing core services specifically conceived to support translational research in these diseases (e.g., neurophysiology, neuropathology, NMR/metabolomics, behavior, pharmacology/preclinical drug trials, mathematics/bioinformatics). TCH raised money for most of the first phase of this project, completed a 13-floor building shell, and will complete Floors 1 (admin, conference rooms), 3 (animal facility), 12, 13 and part of 11 by late 2010. This is insufficient, however, to allow NRI to begin functioning as it should. To accomplish that, we need to finish: Floor 11 (7025 sf) to recruit three new faculty; Floor 10 (22,705 sf) to relocate five BCM faculty performing neuropsychiatric disease-oriented research and recruit three new faculty; and Floor 2 (6125 sf): space for the NMR Metabolomic Core. As a result of this construction project, we estimate that 192 jobs directly assisting with construction will be maintained or created; recruiting new PIs over the next 3 years to the NIH-finished floors would create 100 jobs in the short-to-intermediate term. Based on previous data calculating the impact of the medical center on the Houston area economy, we estimate that every NRI employee will indirectly support three other jobs in the Houston region, and that every dollar invested in NRI generates $1.44 in local tax revenue. Ultimately, however, the discovery of treatments for these devastating diseases will restore quality of life and reduce their terrible economic burden on families and society.

描述（由申请人提供）：该提案的目的是在Jan和Dan Duncan神经研究所（NRI）中建立3层（总数），以加快理解和治疗大脑和心灵障碍的研究。贝勒医学院（BCM）和德克萨斯州儿童医院（TCH）的研究人员通过六个NIH研究所，HHMI和几个疾病基础的支持，一直处于揭示许多神经系统和神经发育障碍的分子遗传学的最前沿。这些疾病的出色动物模型以及几种（在小鼠中证明）的潜在可逆性的可用性使它们非常适合于艰苦的多学科努力来开发治疗。 BCM和TCH构思了NRI，这是350,000平方英里的LEED认证研究所，连接BCM，TCH和MD Anderson，成为世界上第一个致力于儿童神经疾病的研究所。 NRI将通过1）通过1）在一个屋顶下从事这些疾病工作的当前BCM/TCH研究人员来促进转化研究药物试验，数学/生物信息学）。 TCH为该项目的大部分阶段筹集了资金，完成了13层的建筑物外壳，并将完成1（管理室，会议室），3（动物设施），12、13和2010年下午11点的一部分。但是，这不足以允许NRI开始运作。为此，我们需要完成：11楼（7025平方英尺）以招募三个新教师；第10楼（22,705平方英尺）搬迁五名BCM教职员工，以神经精神疾病为导向的研究并招募三个新教师；和2楼（6125平方英尺）：NMR代谢组核的空间。由于这个建设项目，我们估计将维护或创建直接辅助建筑的192个工作；在接下来的3年中招募新的PI到NIH成立的楼层将在短期任期内创造100个工作岗位。基于以前计算医疗中心对休斯顿地区经济的影响的数据，我们估计每个NRI员工将间接支持休斯敦地区的其他三个工作，并且在NRI上投资的每一美元都会产生1.44美元的本地税收收入。然而，最终，发现这些毁灭性疾病的治疗方法将恢复生活质量，并减轻他们对家庭和社会的可怕经济负担。