Treatment of Depressed Adolescents with Physical Illness

患有身体疾病的抑郁青少年的治疗

• 批准号: 7127730
• 负责人: EVA M SZIGETHY
• 金额: $ 16.38万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7127730
• 关键词: adolescence (12-20); anxiety; behavioral /social science research tag; clinical research; clinical trials; cognitive behavior therapy; comorbidity; corticosteroids; family structure /dynamics; family therapy; functional ability; gastrointestinal disorder chemotherapy; gender difference; human subject; human therapy evaluation; inflammatory bowel diseases; longitudinal human study; major depression; neuropsychological tests; neuropsychology; patient oriented research; postdoctoral investigator; problem solving; questionnaires; social behavior

DESCRIPTION (provided by applicant): The identification and treatment of depressive disorders in adolescents with chronic physical illness is an understudied area. The purpose of this Mentored Patient-Oriented Research Development Award (K23) is to enable the candidate to become an independent clinical researcher in the area of innovative approaches to evaluation and treatment of depression in adolescents facing physical illnesses. The proposal will focus on patients with inflammatory bowel disease (IBD). The project will be conducted at Children's Hospital Boston (CHB), where a large population of adolescents with IBD is available. William R. Beardslee, MD, with expertise in depressive disorders and prevention, will serve as the primary mentor. John March, MD, MPH and John Weisz, PhD, experts in clinical psychiatric outcome research and psychotherapy interventions, will serve as co-sponsors. Research plan: The aims are: 1) Conduct randomized comparison trial of cognitive behavioral therapy (CBT) enhanced with physical illness narrative, family education, and social skills components (n=24) to standard of community care treatment (n=24) in depressed adolescents with IBD, and 2) Investigate underlying neurobehavioral changes in adolescents with depression and IBD. Career development plan: The training will emphasize skills necessary for conducting comparative clinical trials in the treatment of depression in adolescents with chronic physical illness and begin to explore underlying neurological mechanisms of the disease process. Didactic work in intervention research design and statistics, developmental psychopathology, and assessment of methodologies for biological and neurobehavioral correlates of treatment response will complement supervision by the program consultants. With a sound understanding of pathobiology and change mechanisms, the long-term goals of the candidate are to develop and evaluate cognitive-behavioral and pharmacological treatments for physically ill children and adolescents with depression and to investigate neurobiological correlates of treatment effect.

描述（由申请人提供）：患有慢性身体疾病的青少年抑郁症的识别和治疗是一个尚未充分研究的领域。 这项以患者为导向的研究开发奖（K23）的目的是使候选人能够成为评估和治疗患有身体疾病的青少年抑郁症的创新方法领域的独立临床研究员。 该提案将重点关注炎症性肠病（IBD）患者。 该项目将在波士顿儿童医院 (CHB) 进行，那里有大量患有 IBD 的青少年。 William R. Beardslee 医学博士在抑郁症和预防方面拥有丰富的专业知识，他将担任主要导师。 临床精神病学结果研究和心理治疗干预方面的专家约翰·马奇 (John March) 医学博士、公共卫生硕士和约翰·韦兹 (John Weisz) 博士将作为共同发起人。 研究计划：目标是： 1) 在以下地区开展认知行为疗法 (CBT) 的随机比较试验，该疗法以身体疾病叙述、家庭教育和社交技能成分 (n=24) 为基础，与社区护理治疗标准 (n=24) 相结合。患有 IBD 的抑郁青少年，以及 2) 调查患有抑郁症和 IBD 的青少年潜在的神经行为变化。 职业发展计划：培训将强调在患有慢性身体疾病的青少年抑郁症治疗中进行比较临床试验所需的技能，并开始探索疾病过程的潜在神经机制。 干预研究设计和统计、发展精神病理学以及治疗反应的生物和神经行为相关方法评估等方面的教学工作将补充项目顾问的监督。 凭借对病理学和变化机制的深入了解，候选人的长期目标是开发和评估针对患有抑郁症的身体疾病儿童和青少年的认知行为和药物治疗，并研究治疗效果的神经生物学相关性。

项目成果

Longitudinal results of cognitive behavioral treatment for youths with inflammatory bowel disease and depressive symptoms.

患有炎症性肠病和抑郁症状的青少年认知行为治疗的纵向结果。

• DOI: 10.1007/s10880-012-9301-8
• 发表时间: 2012
• 期刊: Journal of clinical psychology in medical settings
• 影响因子: 2.2
• 作者: Thompson,RachelD;Craig,Anna;Crawford,EmilyA;Fairclough,Diane;Gonzalez-Heydrich,Joseph;Bousvaros,Athos;Noll,RobertB;DeMaso,DavidR;Szigethy,Eva
• 通讯作者: Szigethy,Eva

Case study: longitudinal treatment of adolescents with depression and inflammatory bowel disease.

案例研究：患有抑郁症和炎症性肠病的青少年的纵向治疗。

• DOI: 10.1097/01.chi.0000198591.45949.a4
• 发表时间: 2006
• 期刊: Journal of the American Academy of Child and Adolescent Psychiatry.
• 作者: Szigethy,Eva;Carpenter,Johanna;Baum,Emily;Kenney,Elyse;Baptista-Neto,Lourival;Beardslee,WilliamR;Demaso,DavidRay
• 通讯作者: Demaso,DavidRay

Using the Children's Depression Inventory in youth with inflammatory bowel disease: support for a physical illness-related factor.

在患有炎症性肠病的青少年中使用儿童抑郁量表：支持身体疾病相关因素。

• DOI: 10.1016/j.comppsych.2012.04.006
• 发表时间: 2012
• 期刊: Comprehensive psychiatry
• 影响因子: 7.3
• 作者: Thompson,RachelD;Craig,AnnaE;Mrakotsky,Christine;Bousvaros,Athos;DeMaso,DavidR;Szigethy,Eva
• 通讯作者: Szigethy,Eva