TB Clinical Research: Training the Next Generation

结核病临床研究：培训下一代

• 批准号: 7033841
• 负责人: Carol D Hamilton
• 金额: $ 9.71万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7033841
• 关键词: bioinformatics; clinical research; clinical trials; combination chemotherapy; drug administration rate /duration; drug screening /evaluation; epidemiology; genetic susceptibility; genotype; health care personnel; human genetic material tag; human subject; human therapy evaluation; isoniazid; latent bacterial disease; patient care management; patient oriented research; public health; respiratory disease /disorder therapy; respiratory disorder diagnosis; rifamycins; single nucleotide polymorphism; statistics /biometry; training; tuberculin test; tuberculosis

DESCRIPTION (provided by applicant): The Investigator, Carol Dukes Hamilton, M.D., will use NIH K24 funding to help train future generations of clinical-scientists for a career in tuberculosis (TB) research. TB is responsible for more human deaths than any other infectious disease. Dr. Hamilton's long-term research goals are to optimize strategies for treating active and latent TB in adults and children. Strengths of her program include ongoing funding and active participation in the CDC-funded TB Trials Consortium clinical trials group, the CDC-funded TB Epidemiologic Studies Consortium, and an NHLBI-funded study of genetics of TB susceptibility. These funded programs form the basis of her research enterprise. They combine perfectly with the opportunities afforded by her position as the Medical Director for North Carolina's TB Control Program, providing an avenue for subject recruitment, clinical and epidemiologic research training for advisees, and the opportunity to implement changes based on the findings. The strength of Dr. Hamilton's TB research program is that she employs both clinical trials and epidemiologic studies to attain her research goals. Trainees can tap into one or the other methodologies during their training. Didactic course work leading to either a Masters in Clinical Research Science or Public Health is an integral part of Dr. Hamilton's mentoring plan. Dr. Hamilton will also strengthen her experiencebased research capability using these resources. Dr. Hamilton's research plan includes a description of the TB Trials Consortium clinical trial, "Study 26", comparing the effectiveness of 9 months of daily isoniazid therapy to 12 doses of weekly isoniazid plus rifapentine, for treatment of latent TB infection. Planned and potential sub-studies and secondary analyses provide fertile substrate for trainee-initiated research projects. The research plan also includes her NHLBI funded genetic epidemiologic study of candidate genes that may contribute to human TB susceptibility. Her work with the Duke Center for Human Genetics is an example of translational research she hopes to foster within her mycobacteria research program.

描述（由申请人提供）：研究者 Carol Dukes Hamilton 医学博士将利用 NIH K24 资金帮助培训未来几代临床科学家从事结核病 (TB) 研究工作。结核病造成的人类死亡比任何其他传染病都要多。汉密尔顿博士的长期研究目标是优化治疗成人和儿童活动性和潜伏性结核病的策略。她的项目的优势包括持续资助和积极参与 CDC 资助的结核病试验联盟临床试验小组、CDC 资助的结核病流行病学研究联盟以及 NHLBI 资助的结核病易感性遗传学研究。这些资助的项目构成了她的研究事业的基础。它们与她作为北卡罗来纳州结核病控制项目医学主任所提供的机会完美结合，为受试者招募、为顾问提供临床和流行病学研究培训以及根据研究结果实施变革的机会提供了途径。 汉密尔顿博士的结核病研究项目的优势在于她采用临床试验和流行病学研究来实现她的研究目标。受训者可以在培训期间采用一种或另一种方法。获得临床研究科学或公共卫生硕士学位的教学课程是汉密尔顿博士指导计划的一个组成部分。汉密尔顿博士还将利用这些资源加强她基于经验的研究能力。 Hamilton 博士的研究计划包括对结核病试验联盟临床试验“研究 26”的描述，该试验比较了 9 个月每日异烟肼治疗与每周 12 剂异烟肼加利福喷汀治疗潜伏性结核感染的有效性。计划的和潜在的子研究以及二次分析为学员发起的研究项目提供了肥沃的基础。该研究计划还包括她由 NHLBI 资助的对可能导致人类结核病易感性的候选基因的遗传流行病学研究。她与杜克大学人类遗传学中心的合作是她希望在分枝杆菌研究项目中促进转化研究的一个例子。