Sleep Fragmentation and Attention in Alzheimer's Disease

阿尔茨海默病的睡眠碎片化和注意力

• 批准号: 7144853
• 负责人: CATHERINE Sue COLE
• 金额: $ 9.55万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-01 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7144853
• 关键词: Alzheimer' s disease; REM sleep; attention; behavioral /social science research tag; clinical research; cognition; human subject; pathologic process; patient oriented research; polysomnography; psychic activity level; sleep deprivation; wakefulness

DESCRIPTION (provided by applicant): The overarching goal of this proposed 3 year career development award is (PWAD). Specifically, I will 1) pursue advanced training in the use and interpretation of objective measurements of sleep and cognition in PWAD, 2) gain detailed knowledge of mechanisms underlying sleep and the cognitive manifestations of AD, and 3) acquire the skills needed to build a program of research aimed at understanding the mechanisms of acute and chronically fragmented sleep and its effect on PWAD. In addition to coursework, guided studies, and attendance at professional meetings. I propose to begin by investigating the effect of 1 night of sleep fragmentation and 1 night of undisturbed recovery sleep on attention in PWAD. Although there is beginning evidence that sleep fragmentation affects attention in persons without cognitive impairment, no one has studied it in PWAD. Alzheimer's disease is primarily thought of as a disease of impaired memory and although attention is not the same as memory, the ability to pay attention is a prerequisite for memory and the inability to pay attention may cause or worsen memory complaints. I am an advanced practice nurse and in my practice I have cared for older adults, many of whom had dementia. Postdoctoral study at the University of Arkansas for Medical Sciences with Drs. Kathy Richards and Cornelia Beck has opened a new career path in the area of sleep research in PWAD that has the potential to increase understanding of the short-term and long-term effects of sleep fragmentation on cognition in PWAD and hopefully, to target interventions that will slow their memory decline. But I am a novice in this field and need the additional time a career development award provides to continue to develop expertise. Since our mutual commitment to this project I have worked to develop a proposal that will complement and not duplicate Drs. Richards and Beck's work.

描述（由申请人提供）：拟议的3年职业发展奖的总体目标是（PWAD）。具体来说，我将1）在PWAD中对睡眠和认知的客观测量的使用和解释进行高级培训，2）获得对睡眠的机制以及AD的认知表现的详细知识，以及3）获得了旨在建立旨在了解敏锐和碎片睡眠机制的研究计划所需的技能。除了课程，指导学习和参加专业会议外。我建议首先调查1晚睡眠破碎化和1晚不受干扰的恢复睡眠对普华顾问的关注的影响。尽管有证据表明睡眠破裂会影响没有认知障碍的人的注意力，但没有人在普华永道中进行研究。阿尔茨海默氏病主要被认为是一种记忆力受损的疾病，尽管注意力与记忆不同，但注意力的能力是记忆的先决条件，无法引起注意的能力可能引起或恶化记忆投诉。我是一名高级练习护士，在我的练习中，我照顾了老年人，其中许多人患有痴呆症。阿肯色大学医学科学大学的博士后研究。凯西·理查兹（Kathy Richards）和科特里亚·贝克（Cornelia Beck）在普华怀当度的睡眠研究领域开辟了一条新的职业道路，有可能增进对PWAD的睡眠分散对认知的短期和长期影响的理解，并希望目标干预措施会减缓其记忆力下降。但是我是该领域的新手，需要一项职业发展奖提供的额外时间，以继续发展专业知识。由于我们对这个项目的共同承诺，我一直在努力制定一项将补充而不是重复Drs的建议。理查兹和贝克的作品。