Feasibility Study: Attention Measures in Persons with Alzheimer's Disease

可行性研究：阿尔茨海默病患者的关注措施

• 批准号: 7253643
• 负责人: CATHERINE Sue COLE
• 金额: $ 14.29万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7253643
• 关键词: Academic Research Enhancement Awards; Address; Admission activity; Age; Alzheimer' s Disease; Anxiety; Attention; Behavioral Symptoms; Caregiver Burden; Caregivers; Characteristics; Circadian Rhythms; Clinical; Computer software; Condition; Data; Depressed mood; Devices; Disruption; Education; Enrollment; Ensure; Feasibility Studies; Frequencies; Goals; Hour; Human; Impaired cognition; Institutes; Knowledge; Laboratories; Learning; Measures; Memory; Mission; Moods; Motivation; Motor; Neurons; Nursing Homes; Nursing Research; Participant; Performance; Persons; Population; Principal Investigator; Printing; Quality of life; Reaction Time; Reporting; Research; Research Personnel; Sensory; Severities; Sleep; Stimulus; Strategic Planning; Testing; Time; Visual; computerized; design; experience; falls; improved; millisecond; programs; response; stimulus processing; tool; vigilance; Academic Research Enhancement Awards; Address; Admission activity; Age; Alzheimer' s Disease; Anxiety; Attention; Behavioral Symptoms; Caregiver Burden; Caregivers; Characteristics; Circadian Rhythms; Clinical; Computer software; Condition; Data; Depressed mood; Devices; Disruption; Education; Enrollment; Ensure; Feasibility Studies; Frequencies; Goals; Hour; Human; Impaired cognition; Institutes; Knowledge; Laboratories; Learning; Measures; Memory; Mission; Moods; Motivation; Motor; Neurons; Nursing Homes; Nursing Research; Participant; Performance; Persons; Population; Principal Investigator; Printing; Quality of life; Reaction Time; Reporting; Research; Research Personnel; Sensory; Severities; Sleep; Stimulus; Strategic Planning; Testing; Time; Visual; computerized; design; experience; falls; improved; millisecond; programs; response; stimulus processing; tool; vigilance

DESCRIPTION (provided by applicant): This study will establish the feasibility of using repeated simple reaction time measures to study the effect of sleep disruption on vigilant attention in persons with AD. Sleep disruption is a prominent clinical feature of AD that significantly impacts quality of life for persons with AD and their caregivers. In healthy people, studies of sleep disruption show the negative effects of sleep disruption and the positive effects of improved sleep on motor function, mood, and vigilant attention. Impaired vigilant attention is highly significant because intact vigilant attention is central to human function. The ability to vigilantly attend to, quickly select and respond to the most salient incoming stimuli for processing is essential for safe and effective human performance. Impaired vigilant attention is particularly important for persons with AD because the inability to maintain vigilant attention may cause or worsen memory complaints. Although the impact of sleep disruption on vigilant attention has been studied extensively in healthy people the availability of strong evidence concerning its effect on persons with AD is limited. To the Principal Investigator's (PI) knowledge, no one has studied the effect of sleep disruption on vigilant attention in persons with AD. However, before we can study the effect of sleep disruption on vigilant attention in persons with AD, we must ensure that we have valid and reliable measures of vigilant attention. In healthy populations repeated simple reaction time measures (The Psychomotor Vigilance Task [PVT]) have successfully been used to study the effect of sleep disruption on vigilant attention. The PVT was developed by Dinges and Powell (1986) as a standardized laboratory tool and has been used extensively by sleep researchers in healthy populations. The PVT is a simple small handheld device that can be programmed to deliver either a visual or audible multiple unprepared reaction time tests. Each trial lasts 10 minutes. Although the reaction time paradigm has been used to assess vigilant attention in persons with mild AD in a cross sectional design, we do not know if persons with AD can complete multiple repeated measures or if the results obtained might be erroneous. For example, changes in attention may erroneously reflect depressed motivation or anxiety with the testing situation. Therefore, the primary specific aim for this study is: 1. Determine the feasibility of using frequently repeated (q 2 hour) measures of vigilant attention (PVT) in persons with AD. The secondary specific aims are: 2. Determine the sensitivity of PVT tests across 6 time periods to measure changes in vigilant attention in persons with AD. 3. Determine the sensitivity of PVT tests of less than 10 minutes duration. This application is submitted under the Academic Research Enhancement Award (R15) Announcement (PA- 06-042). The proposed study will establish the feasibility of using repeated simple reaction time measures to study the effect of sleep disruption on vigilant attention in persons with Alzheimer's disease. This feasibility study addresses Goal 2.1: Research in neurofunction and sensory conditions, as outlined in the National Institute on Nursing Research Mission Statement and Strategic Plan.

描述（由申请人提供）：本研究将建立使用重复的简单反应时间指标来研究睡眠中断对AD患者保持警惕的影响的可行性。睡眠中断是广告的重要临床特征，它会严重影响AD及其护理人员的人的生活质量。在健康的人中，睡眠中断的研究表明睡眠中断的负面影响以及改善睡眠对运动功能，情绪和警惕的关注的积极影响。警惕的注意力受损是非常重要的，因为完整的警惕关注对人类功能至关重要。警惕，快速选择并应对处理最显着的刺激的能力对于安全有效的人类表现至关重要。警惕的注意力受损对于AD患者尤为重要，因为无法保持警惕的关注可能会导致或恶化记忆投诉。尽管在健康人中广泛研究了睡眠中断对警惕关注的影响，但有很大的证据表明其对AD患者的影响是有限的。对于主要研究者（PI）知识，没有人研究睡眠中断对AD患者保持警惕的影响。但是，在我们可以研究睡眠中断对AD的人保持警惕的影响之前，我们必须确保我们对注意力有效，可靠地衡量。在健康的人群中，重复的简单反应时间措施（精神运动警惕任务[PVT]）已成功地用于研究睡眠中断对警惕关注的影响。 PVT由Dinges和Powell（1986）作为标准化实验室工具开发，并已被健康人群的睡眠研究人员广泛使用。 PVT是一种简单的小型手持设备，可以对其进行编程，以提供视觉或可听见的多个未准备好的反应时间测试。每个试验持续10分钟。尽管反应时间范式已被用来评估横截面设计中轻度AD的人的警惕注意力，但我们不知道具有AD的人是否可以完成多次重复测量，或者获得的结果是否可能是错误的。例如，注意力的变化可能会错误地反映在测试情况下的动机或焦虑。因此，这项研究的主要特定目的是：1。确定在AD患者中使用经常重复重复（Q 2小时）保持警惕（PVT）的可行性。次要特定目的是：2。确定在6个时期内PVT测试的敏感性，以衡量AD患者警惕的注意力的变化。 3。确定持续时间少于10分钟的PVT测试的灵敏度。该申请是根据“学术研究增强奖”（R15）公告（PA-06-042）提交的。拟议的研究将确定使用重复的简单反应时间措施来研究睡眠破坏对患有阿尔茨海默氏病的人保持注意力的影响。这项可行性研究解决了目标2.1：神经功能和感官状况的研究，如美国国家护理研究任务说明和战略计划中所述。