Re-Engineering the Clinical Research Enterprise

重新设计临床研究企业

• 批准号: 7058409
• 负责人: GREGORY H REAMAN
• 金额: --
• 依托单位: NATIONAL CHILDHOOD CANCER FOUNDATION
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2007-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7058409
• 关键词: bone marrow transplantation; clinical research; clinical trials; health science research support; informatics; interdisciplinary collaboration; pediatric neoplasm /cancer

The broad, long-term objective is to develop a collaborative effort between two clinical trials networks, the Pediatric Blood and Marrow Transplant Consortium (PBMTC) and the Children's Oncology Group (COG), in order to enhance the availability, safety, and efficacy of Pediatric blood and marrow transplantation performed by the PBMTC and COG, jointly optimize BMT protocol performance by the PBMTC and cancer treatment by the COG, and to advance the science and application of BMT through coordinated development of research concepts and collection of data between the PBMTC, the COG, and related networks in BMT. The specific aims include: 1. To expand COG's clinical trails infrastructure to enable an inter-operable clinical research network in pediatric BMT in conjunction with PBMTC. 2. To evaluate the performance of the infrastructure and inter-network informatics applications to actual inter-group clinical trials. 3. To develop standardized informatics tools that will allow for optimal data sharing of clinical research data from clinical trials between the COG/PBMTC and other networks.

广泛的长期目标是在两个临床试验网络之间建立协作努力，即小儿血液和骨髓移植财团（PBMTC）（PBMTC）和儿童肿瘤学小组（COG），以增强通过PEL和Marrow Transtration PRBER的效率，以增强PBMT和COG的效率，以提高PBMT和COG的效率。通过COG进行癌症治疗，并通过协调的研究概念的协调开发以及BMT中PBMTC，COG和相关网络之间的数据收集来推动BMT的科学和应用。 具体目的包括： 1。为了扩展COG的临床基础设施，以与PBMTC结合使用小儿BMT的互操作临床研究网络。 2。评估对实际组间临床试验的基础设施和网络间信息学应用程序的性能。 3。开发标准化的信息学工具，从而可以从COG/PBMTC和其他网络之间的临床试验中最佳数据共享临床研究数据。