Generalized Anxiety Disorder and Social Anxiety Disorder

广泛性焦虑症和社交焦虑症

• 批准号: 6982839
• 负责人: james r blair
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6982839
• 关键词: amygdala; anxiety disorders; behavioral /social science research tag; comorbidity; frontal lobe /cortex; human subject; neuroimaging; neuropsychology; patient oriented research; social behavior; socioenvironment

There have been suggestions that the threshold for amygdala activity is lower in individuals with anxiety disorders than in healthy individuals. However, despite its immediate plausibility, there have been relatively few tests of this hypothesis. Specifically, there have been very few explorations of the performance of patients with anxiety disorders on measures known to implicate the amygdala. Although the high co-morbidity of Generalized Anxiety Disorder (GAD) and Social Anxiety Disorder (SAD) complicates the issue, the fact that the disorders doubly dissociate suggests that they are due to dysfunctional activity in separable neuro-cognitive systems. We would suggest that the hyper-responsive amygdala hypothesis is more likely to be linked to the explanation of GAD. In contrast, SAD may be due to reduced activation thresholds for units in a system that responds to social threat and which recruits lateral orbital frontal cortex. Thus, the current project will determine the performance of patients with GAD and SAD on measures in which the amygdala is known to play a role and also in measures that recruit lateral orbital frontal cortex and the system for social response reversal. In addition, two proposed neuro-imaging studies will directly assess neural responses in these two systems in both patient populations. The project aims to provide clear data that will inform future theorizing on the pathology implicated in these two disorders.

有人提出，焦虑症患者的杏仁核活性的阈值比健康个体低。但是，尽管具有直接的合理性，但对此假设的检验却相对较少。具体而言，很少有人探索焦虑症患者对已知牵涉杏仁核的措施的表现。 尽管普遍焦虑症（GAD）和社交焦虑症（SAD）的高杂菌症使问题复杂化，但疾病双重分离的事实表明，它们是由于可分开的神经认知系统中功能障碍的活性所致。我们建议，超响应性杏仁核假说更有可能与GAD的解释有关。相比之下，SAD可能是由于对社会威胁响应并招募横向轨道额叶皮质的系统中单位的激活阈值降低所致。因此，当前的项目将确定GAD患者的表现和对杏仁核可以发挥作用的措施的措施，以及在募集横向轨道额叶皮层和社会反应逆转系统的措施中发挥作用。此外，两项提出的神经成像研究将直接评估这两个患者人群中这两个系统的神经反应。该项目旨在提供清晰的数据，以使未来的理论化这两种疾病所涉及的病理。