Advanced Research Cooperation In Environmental Health S*

环境健康高级研究合作 S*

• 批准号: 6784744
• 负责人: Romonia Renee REAMS
• 金额: $ 85.16万
• 依托单位: FLORIDA AGRICULTURAL AND MECHANICAL UNIV
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-25 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6784744
• 关键词: biological signal transduction; environmental health; environmental toxicology; minority institution research support

DESCRIPTION (provided by applicant): Faculty members at Florida A&M University (FAMU), in partnership with faculty in the Institute of Chemical Toxicology and Environmental Health Science (EHS) Center in Molecular and Cellular Toxicology with Human Applications at Wayne State University are proposing an advanced research cooperation program in basic environmental health sciences. This program will provide the infrastructure required for mentoring and developing Florida A&M faculty in the use of contemporary concepts in molecular and cell biology and related experimental approaches and technologies such that these investigators will be able to pursue studies of the molecular mechanisms by which environmental chemicals modulate the response of cells and tissues. The research focus of investigators in this initiative is signal transduction, an emerging contemporary research area of great importance to environmental toxicology, since it is becoming increasingly apparent that toxicants exert their biological actions by interfering with inter- and intra-cellular signaling pathways that affect gene expression and cellular function. The research objective of this program is to assist Florida A&M faculty in the development of contemporary concepts, approaches, and technologies for elucidating mechanisms associated with disruption of signal transduction pathways, second messengers, and effectors as a consequence of exposure to environmental agents. The primary objective of this program is to establish mentoring relationships, which will develop into collaborative interactions and will result in publication of manuscripts in high quality peer-reviewed journals and the funding of competitive peer-reviewed research grant applications. The specific objectives to be accomplished include assisting Florida A&M University faculty with 1) the development of specific objectives derived from a hypothesis-based concept which will result in an RO1-type grant submission, 2) the planning and execution of experiments designed to provide preliminary data in support of peer-reviewed grant applications, 3) in the use of contemporary molecular, cellular, or immunological cDNA array and RT-PCR approaches, 4) with guidance in the purchase of equipment and establishment of a core facility, 5) with a mentoring-intensive education/enrichment program, 6) with the production and submission of manuscripts to peer-review journals and grant applications, 7) through reviewing submitted manuscripts and grant proposals, 8) through attaining R01-like funding for the mentored faculty within the time frame of this grant, preferably within four years. External and Internal Advisory Boards, scheduled meetings and laboratory rotations, and specific objectives have been identified. Pilot projects have been established between Florida A&M University faculty in the College of Pharmacy and Pharmaceutical Sciences and FAMU Environmental Sciences Institute and faculty in the Institute of Chemical Toxicology and EHS Center. It is envisioned that through these interactions and objectives the research capacity of investigators at Florida A&M University will be enhanced.

描述（由申请人提供）： 佛罗里达农工大学（FAMU）的教职员工与教师合作 在化学毒理学与环境健康科学研究所（EHS） 在韦恩的人类应用中，分子和细胞毒理学的中心 州立大学提出了一项高级研究合作计划 基本环境健康科学。该程序将提供 指导和发展佛罗里达A＆M教师所需的基础设施 在分子和细胞生物学以及相关的分子和细胞生物学中使用当代概念 实验方法和技术，使这些研究者将是 能够研究环境的分子机制 化学物质调节细胞和组织的反应。研究重点 该计划中的研究人员是信号转导，一种新兴 当代研究领域对环境毒理学非常重要， 由于越来越明显的是，有毒者发挥他们的作用 通过干扰细胞间和细胞内信号传导来生物学作用 影响基因表达和细胞功能的途径。研究 该计划的目的是协助佛罗里达A＆M教师开发 阐明当代概念，方法和技术 与信号转导途径中断相关的机制，第二 使者和效应子是由于暴露于环境而导致的 代理商。该计划的主要目的是建立指导 关系，将发展为协作互动，并将 导致在高质量的同行评审期刊上发布手稿 以及竞争性同行评审的研究赠款申请的资金。这 要实现的具体目标包括协助佛罗里达A＆M 大学教职员工1）从 一个基于假设的概念，将导致RO1型赠款提交， 2）旨在提供初步的实验的计划和执行 支持同行评审的赠款应用程序的数据，3） 现代分子，细胞或免疫cDNA阵列和RT-PCR 方法，4）在购买设备和建立的指导下 一个核心设施，5）具有指导密集的教育/丰富计划， 6）随着手稿的生产和提交给同行评审期刊 和赠款申请，7）通过审查提交的手稿和赠款 提案，8）通过获得指导教师的R01式资金 在这笔赠款的时间范围内，最好在四年内。 外部和内部咨询委员会，预定会议和实验室 旋转和特定目标已经确定。试点项目 建立在佛罗里达A＆M大学学院之间 药学和药学科学与FAMU环境科学研究所 以及化学毒理学和EHS中心研究所的教师。这是 设想通过这些互动和目标研究 佛罗里达农工大学的调查人员的能力将得到增强。