Surgical Management of Facial Nerve Injury

面神经损伤的手术治疗

• 批准号: 6985011
• 负责人: THERESA A HADLOCK
• 金额: $ 12.47万
• 依托单位: MASSACHUSETTS EYE AND EAR INFIRMARY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6985011
• 关键词: abnormal involuntary movement; disease /disorder model; facial paralysis; genetically modified animals; innervation; laboratory mouse; laboratory rat; model design /development; nerve injury; nervous system regeneration; neuronal guidance; neuropharmacology

DESCRIPTION (provided by applicant): Facial paralysis represents a devastating clinical problem; management strategies to date remain inadequate. The long term career objective is to improve the clinical management of facial paralysis, by more effectively restoring meaningful movement to the facial musculature. The immediate basic scientific goals are to develop an animal model for the study of facial nerve regeneration, to control the phenomenon of aberrant regeneration (misrouting of axons to an inappropriate muscle target), and to accelerate facial nerve regeneration in the rat using pharmacologic strategies. The long range scientific goals are to utilize emerging peripheral nerve regeneration strategies in this newly developed model to increase the number and target accuracy of axons arriving in the facial musculature after injury or sacrifice. The corresponding decrease in synkinesis (unintentional movement of one region of the face during facial expression), and overall higher neural input will improve clinical facial nerve outcomes. The clinical environment is a busy tertiary care hospital with a specialized facial nerve center and a large population of patients with this uncommon disorder; the research environment is a fully equipped state of the art research facility within the primary hospital and the adjacent hospital. The academic environment is one of complete dedication to advancing both biomedical science and patient care through careful study and diligent investigation, and of support for the mentored investigator.

描述（由申请人提供）：面部瘫痪代表了一个毁灭性的临床问题；迄今为止的管理策略仍然不足。长期职业目标是通过更有效地恢复对面部肌肉的有意义的运动来改善面部瘫痪的临床管理。 直接的基本科学目标是开发一种动物模型，以研究面部神经再生，控制异常再生现象（将轴突误误误以为是不适当的肌肉靶标），并使用药理学策略加速了大鼠的面部神经再生。远程科学目标是在这个新开发的模型中利用新兴的周围神经再生策略，以提高受伤或牺牲后面部肌肉组织到达轴突的数量和目标准确性。同步性的相应减少（面部表达过程中一个面部的一个区域的无意运动）以及总体较高的神经输入将改善临床面部神经结局。 临床环境是一家繁忙的三级护理医院，具有专门的面部神经中心，大量患有这种罕见疾病的患者；研究环境是在初级医院和邻近医院内的艺术研究机构设备齐全的状态。学术环境是通过仔细的研究和勤奋的研究以及对受训者的研究人员的支持，全力以赴地推进生物医学科学和患者护理。