90 KILODALTON HEAT SHOCK PROTEINS

90 千道尔顿热休克蛋白

• 批准号: 6586590
• 负责人: ANDREW K SHIAU
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586590
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; genome; radiography; structural biology

Hsp90 is thought to "chaperone" steroid associates with v-src in the cytoplasm and is thought to be involved in the "maturation" of this and other classes of nonreceptor tyrosine kinases. In order to examine the mechanisms by which these ubiquitous proteins chaperone protein folding and regulate signal transduction, we have overexpressed, purified, and crystallized htpG (high temperature production protein G), the Escherichia coli hsp90 class protein.

Hsp90 被认为是类固醇与 v-src 的“伴侣” 细胞质，被认为参与细胞的“成熟” 这一类和其他类别的非受体酪氨酸激酶。 为了 检查这些普遍存在的蛋白质伴侣的机制 蛋白质折叠和调节信号转导，我们有 过表达、纯化和结晶的 htpG（高温 生产蛋白G)，大肠杆菌hsp90类蛋白。